ECE2016 Eposter Presentations Calcium and Vitamin D metabolism (61 abstracts)
Vitamin D deficiency is highly prevalent in obesity and is related with BMI and inflammation
Jose Carlos Fernandez-Garcia 1, , Fernando Cardona-Diaz 2 , Carmen Maria Cortes-Salazar 3 , Maite Asenjo-Plaza 4 , María Concepción García Ruiz 4 , Enrique Varea-Marineto 4 , María José Banderas-Donaire 4 , Juan Alcaide-Torres 2 , Maria Isabel Queipo-Ortuño 2 , Isabel Moreno-Indias 2 , Mercedes Clemente-Postigo 2 , Daniel Castellano-Castillo 2 & Francisco Tinahones 1,
1Endocrinology Department, Virgen de la Victoria University Hospital, Malaga, Spain; 2Biomedical Research Laboratory, Endocrinology Department, IBIMA, Malaga, Spain; 3Badolatosa Primary Care Centre, Seville, Spain; 4Cruz de Humilladero Primary Care Centre, Malaga, Spain.
Objectives: To study vitamin D deficiency in a cohort of obese males and to evaluate associated clinical and biochemical characteristics.
Methods: Case-control study which included obese (defined by a BMI ≥30 kg/m2) males. Vitamin D deficiency was defined as vitamin D levels <20 ng/ml. Estimation of vitamin D status was determined in serum using a commercially available enzyme- immuno-assay designed to measure 25-OH Vitamin D concentrations in serum or plasma (Immundiagnostik, Quantikine, Bensheim, Germany).
Results: 225 obese males were included in the study. Prevalence of vitamin D deficiency was 51.3%; mean vitamin D levels was 13.8 ng/ml in the group with vitamin D deficiency and 27.3 ng/ml in normal vitamin D status group (P<0.001 for comparison). No differences in age (36.0 vs 37.7, P=0.1), insulin resistance (measured by HOMA-IR index) (5.2 vs 4.3, P=0.11), calcium levels (9.06 vs 9.0 mg/dl), PTH levels (46.1 vs 44 pg/ml, P=0.35) or HbA1c (5.4 vs 5.4, P=0.6) was found between patients with or without vitamin D deficiency, respectively. Patients with vitamin D deficiency were more obese (BMI 40 vs 37.4, P=0.04) and had higher levels of PCR (7.5 vs 5.3 mg/l, P=0.01).
Conclusions: Vitamin D deficiency affects to ~50% of obese males. These patients tend to be more obese and have higher PCR levels than patients with normal concentrations of vitamin D.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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