Endocrine Abstracts

Appropriate treatment of acromegaly results in biochemical control or cure and reduces signs and symptoms, morbidity and excess mortality. Nonetheless, many of these patients still have considerable decreases in quality of life parameters and suffer from increased morbidity due to combinations of factors, including pituitary insufficiency despite optimal endocrine substitution, irreversible effects of previous GH/IGF-1 excess with complex multisystem morbidity, and the effects...

Recent evidence suggests that resolution of hypercortisolism in Cushing’s disease (CD) may not lead to complete remission of the clinical abnormalities associated with this condition. In particular, elevated cardiovascular risk may persist in ‘cured’ CD patients long-term after eucortisolism has been achieved. This is believed to be related with the maintenance of visceral obesity and altered adipokine secretory pattern which perpetuate features of metabolic syn...

Childhood-onset craniopharyngiomas are rare intracranial embryonal malformations of the sellar region arising from remnants of Rathke’s pouch that require life-long control and management of the endocrine, ophthalmological and neuropsychological deficits caused by the tumors and their treatment. Craniopharyngiomas show low-grade histological malignancy and frequently affect hypothalamic/pituitary regions and the optic chiasm due to their location. Hypothalamic involvement...