Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women in their reproductive age. Based on the Rotterdam criteria PCOS is diagnosed by at least two out of the following three criteria: hyperandrogenism, oligo/anovulation, and polycystic ovaries. To date, the underlying cause of PCOS remains unknown, although the elevated androgen levels are suggested to play an important role in the development of PCOS. In addition to ovarian dysfunction, women with PC...

PCOS is associated with increased androgens, elevated insulin and obesity. As obesity and androgens promote insulin resistance and hyperinsulinemia increases ovarian androgen production, and the likelihood of obesity, the interaction between these factors is complex. We investigated the development of insulin resistance, hyperandrogenism and obesity using a clinically realistic ovine model of PCOS. Exposure of the pregnant ewe to increased testosterone from d62 to d102 of gest...

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