Endocrine Abstracts

Bone Marrow Adipose Tissue (BMAT) has only recently become an emerging topic in both medical and basic research. As secretory cells found either packed or scattered within the BM, these adipocytes are likely contributors to haematopoiesis- or bone- related diseases. Indeed, clinical studies have consistently reported that BMAT amount is associated with bone loss in diverse types of osteoporosis such as that of ageing, post-menopause and anorexia nervosa. Since BM adipocytes an...

Bone marrow adipose tissue (BMAT) fills the majority of bone marrow space in adult long bones. Despite its wide presence the functions of BMAT in normal energy metabolism, bone turnover or in disease are largely unknown. Amount of BMAT does increase with age, upon failure of hematopoietic bone marrow and in anorexia nervosa but its amount also positively correlates with that of visceral fat. Work in animal models has suggested that BMAT would share characteristics with brown a...

Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. We have observed region-specific variation in MAT adipocyte development, regulation, size, lipid composition, gene expression and genetic determinants. Functionally, MAT is a disproportionate source of adiponectin. Early MAT formation in mice is conserved, whereas later development is strain dependent. Proximal, but not distal tibial, MAT is lost with 21-day cold exposure. Rat...