Endocrine Abstracts

Purpose: To determine the changes of the choroidal thickness (CT) in diabetes mellitus (DM) type 1 patients without clinical diabetic retinopathy (DR).Methods: We evaulated 50 patients with DM type 1 (50 eyes) and 50 healthy controls (50 eyes) in İzmir Military Hospital from January 2012, through January 2013. DR status was evaluated by indirect fundoscopy and included the study if they have no clinical diabetic retinopathy. Age, gender, duration s...

Background: Impaired bone geometry and/or aberrant bone matrix formation may underlie the increased fracture risk observed in patients with type 1 diabetes mellitus (T1DM). Although reduced areal and volumetric bone mineral density (aBMD, vBMD) have been observed in pediatric and adolescent T1DM patients, few studies have confirmed these observations in adults. Moreover, data on bone geometry in T1DM remain scarce.Objective: To compare areal and volumetr...

Introduction: Recent studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) may have an important role in the treatment of type 2 diabetes mellitus (T2DM). It has been shown that TRAIL deficiency worsens T2DM and that TRAIL delivery, when it is given before disease onset, slows down T2DM development. This study aimed at evaluating whether TRAIL had the potential not only to prevent, but also to treat T2DM.Methods/...

Transplantation of pancreas or isolated Langerhans islets can cure type 1 diabetes. Xenografts from transgenic pigs represent a promising source to overcome the shortage of organ donors. We investigated the immunosuppressive effect of local LEA29Y expression (a high-affinity variant of CTLA4-Ig) by transplantation of neonatal porcine islet-like clusters (NPICCs) from INSLEA29Y transgenic pigs into humanized mice. NPICCs from 1–5 day-old pigs expressing LEA29Y und...

Introduction: Type 2 diabetes represents an important health problem and is designated by a progressive course. Since the vast majority of type 2 diabetic patients are overweight, there is a need not only to avoid weight gain but to lower body weight. Therefore, the usage of drugs that have the potential to lower body weight (GLP1 RA and SGLT2 -inhibitors) should with metformin be preferred initial therapy in the obese and overweight type 2 diabetic patients.<p class="abst...