Endocrine Abstracts

Introduction: DNA methylation is one of the epigenetic mechanisms existing to regulate gene expression. It is believed that methylation of DNA is susceptible of change by environmental and nutritional factors. Thus, epigenetics provides a mechanism which may explain the etiology of some metabolic disorders and obesity.Aim: The aim of this study is to analyze the DNA methylation level of several lipoprotein lipase (LPL)-promoter-CpG island in human viscer...

Background: Several studies suggest health problems in adult patients with CAH. However, data is inconsistent and based on small and relatively young cohorts.The aim of this study was to analyze the metabolic and cardiovascular health in a cohort of 90 adult patients with classic CAH.Subjects and methods: Participants included 90 patients with classic CAH: age range 18–62 years (mean 32.9±10.5, median 29.2) 39 male, 51 fe...

Background: Endogenous Cushing’s syndrome (CS) is rare with an estimated yearly incidence of 1–3 patients/million. CS describes a group of diseases that have in common an excess secretion of glucocorticoids which results in a characteristic clinical phenotype. Severe courses of Cushing’s syndrome are characterized by a break-down of protein catabolism translating into clinical consequences including muscle weakness. While remission of CS is achievable by surgica...

Introduction: Cortisol autonomy may be frequently demonstrated in patients with adrenal incidentaloma and this has been associated to increased cardiovascular (CV) risk. However, only few data are available on CV events and related mortality in such patients. Aims of the study were: 1) to stratify CV events and mortality by the degree of cortisol secretion; 2) to evaluate the effect of adrenalectomy on CV events and mortality.Methods and Design: Data of ...

Introduction: Hypothyroidism has detrimental effects on the cardiovascular system but controversy remains over the benefit of levothyroxine substitution in heart failure (hf). The aim of this register based cohort study was to examine the effects of levothyroxine treatment on all-cause mortality in patients with hf.Methods: The study cohort comprised all Danish citizens aged ≥18 years admitted with hf in 1997–2012 and still alive 30 days after...