ECE2016 Oral Communications Bone & Calcium Homeostasis (5 abstracts)
Ultra-trail marathon induces bone response in association with acute and established metabolic changes
Giovanni Lombardi 1 , Veronica Sansoni 1 , Silvia Perego 1 , Gianluca Vernillo 2, , Federico Schena 3, , Giampiero Merati 2, , Andrea Baruti 6, , Antonio La Torre 2 & Giuseppe Banfi 1,
1I.R.C.C.S. Istituto Ortopedico Galeazzi, Laboratory of Experimentak Biochemistry & Molecular Biology, Milano, Italy; 2University of Milano, Department of Biomedical Sciences for Health, Milano, Italy; 3University of Verona, Research Center for Sport, Mountain & Health, Rovereto, Italy; 4University of Verona, Department of Neurological & Movement Sciences, Verona, Italy; 5IRCCS Fondazione Don Carlo Gnocchi, Milano, Italy; 6University of Milano, Department of Biosciences, Milano, Italy; 7University of Milano, Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata (CIMMBA), Milano, Italy; 8Vita-Salute San Raffaele University, Milano, Italy.
Introduction: Bone and energy metabolisms are deeply related determining a two-way street aimed in regulating the energy utilization [1]. Mountain ultra-marathons are peculiar aerobic performances hardly proving whole body homeostasis [2]. In this study we aimed at investigating and characterizing the metabolic profile (hormones involved in energy metabolism), the metabolic inflammation profile (adipokines), the bone metabolism (bone turnover markers), and their integration (mediated by osteocalcin [3]) both in experienced ultra-marathon runners and control subjects.
Methods: Serum concentrations of bone turnover markers (pro-collagen type I N-terminal propeptide, carboxylated/undercarboxylated osteocalcin), measured by ELISA, and metabolic hormones (C-peptide, insulin, glucagon, glucagon-like peptide, gastric-inhibitory peptide, ghrelin, leptin, resistin, and visfatin), measured by fluorescent-based multiplex assay, were compared before and after a 65-km mountain ultra-marathon in 17 trained runners and in 12 age-matched controls with a low physical activity profile.
Results: After the race, runners experienced a reduction in pro-collagen type I N-terminal propeptide (P< 0.05), although it remained higher than in controls (P< 0.05), while carboxylated osteocalcin remained unchanged. Among the metabolic hormones, only glucagon and leptin were different between runners at rest and controls. C-peptide and leptin decreased after the race in runners, while glucagon, glucagon-like peptide 1, resistin, and visfatin were increased (P< 0.01). Undercarboxylated osteocalcin was decreased (50%, P< 0.05) and highly correlated with insulin and C-peptide (r=0.65, P< 0.01).
Conclusions: In order to keep homeostasis, the energy use is strikingly regulated at expenses of bone metabolism. Undercarboxylated osteocalcin changes clearly mark the global energy needs of the body.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more