Adrenal - Basic & Clinical | 0041 | ECE2016 | 18th European Congress of Endocrinology

ea0041oc1.1 | Adrenal - Basic & Clinical | ECE2016

Genetic landscape of sporadic unilateral adrenocortical adenomas without PRKACA p.Leu206Arg mutation

Ronchi Cristina , Di Dalmazi Guido , Sbiera Silviu , Assie Guillaume , Weigand Isabel , Calebiro Davide , Appenzeller Silke , Rubin Beatrice , Waldmann Jens , Scaroni Carla , Bartsch Detlef , Mantero Franco , Mannelli Massimo , Kastelan darko , Chiodini Iacopo , Bertherat Jerome , Reincke Martin , Strom Tim , Fassnacht Martin , Beuschlein Felix

Genetic alterations affecting the PKA/cAMP pathway are commonly found in cortisol-producing adrenocortical adenomas (ACAs), while activating mutations in the gene coding for β-catenin (CTNNB1) have been reported in both adenomas and carcinomas. However, the molecular pathogenesis of most ACAs is still unclear. Aim of the study was a comprehensive genetic characterization of sporadic ACAs and the identification of novel molecular markers involved in adrenal tumori...

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ea0041oc1.2 | Adrenal - Basic & Clinical | ECE2016

Focal DNA methylation measurement in adrenocortical carcinoma is a prognostic marker independent from tumor stage and Ki67; an ENSAT study

Assie Guillaume , Jouinot Anne , Libe Rossella , Fassnacht Martin , Sbiera Silviu , Ronchi Cristina , De Krijger Ronald , Waldmann Jens , Quinkler Marcus , Tabarin Antoine , Chabre Olivier , Mantero Franco , Mannelli Massimo , Kerlan Veronique , Groussin Lionel , Baudin Eric , Beuschlein Felix , Clauser Eric , Coste Joel , Bertherat Jerome

Recent pan-genomic analyses of tumor DNA identified specific patterns of DNA methylation e.g. CpG islands hypermethylation in the promoter regions of genes- as pejorative prognostic markers in adrenocortical cancer (ACC). Integrated genomics clearly shows that ACC with such an hypermethylation belongs to specific subgroups of ACC with increased driver genes alterations and a poor survival.Aim: To confirm the prognostic value of this methylation pat...

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ea0041oc1.3 | Adrenal - Basic & Clinical | ECE2016

Hormone replacement therapy with prednisolone is associated with a worse lipid profile than replacement with hydrocortisone in patients with adrenal insufficiency: a matched analysis of data from the EU-AIR

Quinkler Marcus , Ekman Bertil , Marelli Claudio , Uddin Sharif , Zelissen Pierre , Murray Robert

Introduction: Prednisolone is the standard treatment for most inflammatory conditions. However, it is also used in hormone replacement therapy in adrenal insufficiency (AI) for historical reasons or due to its longer half-life and once-daily application. Recent data indicate that daily prednisolone could be associated with lower bone mineral density than daily hydrocortisone in patients with AI. However, data on risk factors for cardiovascular disease in patients with AI treat...

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ea0041oc1.4 | Adrenal - Basic & Clinical | ECE2016

Urine steroid metabolomics is a highly sensitive tool for post-operative recurrence detection in adrenocortical carcinoma

Chortis Vasileios , Bancos Irina , Sitch Alice J , Taylor Angela E , O'Neil Donna , Lang Katharina , Quinkler Marcus , Terzolo Massimo , Mannelli Massimo , Vassiliadi Dimitra , Ambroziak Urszula , Dennedy M. Conall , Sherlock Mark , Bertherat Jerome , Beuschlein Felix , Fassnacht Martin , Deeks Jonathan J , Biehl Michael , Arlt Wiebke

Context: Adrenocortical carcinoma (ACC) is an aggressive malignancy with high recurrence rates. Regular post-operative follow-up imaging is essential, but associated with high radiation exposure and frequent diagnostic ambiguity. Urine steroid metabolomics has been described as a novel diagnostic tool for the detection of adrenocortical malignancy. Here we present the first clinical study assessing the performance of this innovative approach in the follow-up of patients with c...

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ea0041oc1.5 | Adrenal - Basic & Clinical | ECE2016

Is biochemical assessment of pheochromocytoma necessary in adrenal incidentalomas with magnetic resonance features non-suggestive of pheochromocytoma?

Kuzu Idris , Zuhur Sayid Shafi , Ozel Alper , Ozturk Feyza Yener , Altuntas Yuksel

Objective: It is not currently well known whether pheochromocytomas can be ruled out based on low intensity on T2-weighted sequences and signal loss on out-off phase magnetic resonance imaging (MRI) sequences. Hence, in this study we aimed to investigate whether biochemical screening for pheochromocytoma in patients with adrenal incidentalomas (AI) showing MRI features not suggesting pheochromocytoma would prove beneficial.Methods: We performed MRI for 3...

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