ECE2016 Guided Posters Thyroid - Translational & Clinical (10 abstracts)
Betatrophin level in Hashimoto thyreoiditis
Anna Poplawska-Kita 1 , Katarzyna Siewko 1 , Maria Kosciuszko-Zdrodowska 1 , Danuta Lipinska 1 , Robert Milewski 2 , Lukasz Poplawski 1 , Malgorzata Szelachowska 1 & Maria Gorska 1
1Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok, Poland; 2Department of Statistics and Medical Informatics, Medical University, Bialystok, Poland.
Aim: Clinical studies in Hashimoto thyroditis (HT) confirm, that even a minor thyroid dysfunction is related to significant changes in body mass. Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver and adipose tissue. Stimulators of betatrophin, such as thyroid hormones are usually relevant to energy expenditure or thermogenesis. The mechanisms of action of betatrophin are still unknown. In the present study we aimed to find out the relation between HT, obesity and betatrophin level.
Material and methods: The group studied consisted of 133 patients with HT in euthyreosis and 42 healthy individuals. All the patients underwent body mass analysis with the use of a medical analyzer INBODY 220. Serum concentrations of TSH and anti-TSH receptor antibodies (TRAb) were measured using RIA and IgG4, anti-peroxidase antibodies (TPOAb), TNFα, TGF-β1, betatrophin and leptin were measured by commercial ELISA.
Results: The patients with HT had higher level of betatrophin (P=0.008) and TNFα (P=0.01) than had the controls. Observed betatrophin levels are positively correlated with age (P=0.001; P=0.03), body mass (P=0.001; P=0.03), body mass index (BMI) (P=0.000; P=0.000), Waist-Hip Ratio (WHR) (P=0.01; P=0.001) and fat mass (P=0.000; P=0.001) in HT and controls, respectively. In the HT group betatrophin levels correlated significantly with TPOAb (P=0.005; R=0.39). The patients with elevated IgG4 had significantly lower level of TPOAb (P=0.001), betatrophin (P=0.01), BMI (P=0.02), fat mass (P=0.04) and WHR (P=0.001) than the non-IgG4-HT individuals.
Conclusions: Significantly higher betatrophin level in the patients with HT, especially with high level of TPOAb, even in euthyreosis may be cause the increase in fat mass.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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