Endocrine Abstracts

Introduction: Papillary thyroid microcarcinomas (PTMC) are usually considered low-risk tumors with favorable prognosis. However, a small percentage behaves aggressively and controversies exist for various prognostic factors. The aim of this study was to evaluate demographic and tumor specific characteristics related to PTMC invasiveness.Patients – methods: This is a retrospective study of 510 thyroidectomized patients with PTMC who were treated in t...

Background: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid cancer and has no effective therapy. Due to its dismal prognosis, it is vital to understand the genetic alterations of ATC and identify effective molecular targets. We performed targeted next-generation sequencing to investigate the mutational profile of ATC using a massive parallel sequencing approach.Methods: DNA from formalin-fixed, paraffin-embedded archival samples...

Purpose: SPECT/CT has numerous advantages over planar and traditional SPECT images. The aim of this study was to evaluate the role of SPECT/CT after radioiodine treatment of patients with differentiated thyroid cancer (DTC) in early risk classification and in prediction of late prognosis.Methods: One hundred and eighty-one consecutive patients with DTC were investigated after their first radioiodine treatment. The risk for recurrence based on ATA 2009 cl...

Introduction: Follicular neoplasm (FN) or suspicious for a follicular neoplasm category is established by The Bethesda System for Reporting Thyroid Cytopathology because of the necessity to identify a nodule that might be a follicular carcinoma and triage it for surgical lobectomy. Estimated risk of malignancy for this category is 15–30%.Description of methods: We conducted a retrospective study that included all patients with a follicular neoplasm ...

Introduction: Classically, risk stratification in papillary thyroid carcinoma (PTC) assigned the same magnitude of risk to all patients with regional lymph node involvement (N1 disease). However, specific lymph node characteristics (such as size, number, extension, etc.) will allow individualizing treatment and follow-up. One-Step Nucleic Acid Amplification (OSNA) measures the number of copies of mRNA of cytokeratin 19 (CK19) as a marker of lymph node metastasis. Thus, copy nu...

Introduction: Incidental thyroid carcinoma (ITC) in patients operated on for a benign disease is frequent. ITC characteristics in patients operated for malign disease, but not sampled by fine needle aspiration (FNA) or seen in ultrasonography, is unknown. We aimed to compare ITC with nonincidental ITC (NITC) in this study.Material and method: Retrospective analyses of 918 individual patients who were operated for benign and malign thyroid disease in our ...

Introduction: Coexistence of autoimmune thyroiditis (AIT) and papillary thyroid cancer (PTC) has been well documented, but causality is still a matter of debate. Pathogenetic links between PTC and AIT try to explain two theories: 1) PTC is induced or facilitated by AIT, 2) AIT is a response to PTC. It is believed that PTC associated to AIT has a better prognosis.Aims: To find out: 1) the incidence of AIT in PTC patients, 2) the course of PTC associated t...

The well characterized sodium iodide symporter (NIS) in its dual function as reporter and therapy gene displays an outstanding opportunity to target different cancer types allowing non-invasive imaging of functional NIS expression and therapeutic radionuclide application. We recently reported induction of tumor-selective accumulation and therapeutic efficacy of radioiodide after systemic non-viral epidermal growth factor receptor (EGFR)-targeted NIS gene delivery in a subcutan...

Introduction: Undetectable concentration of Tg after rhTSH stimulation (Tg/rhTSH) is one of the most important criteria in evaluating the effectiveness of radioiodine ablation in patients with differentiated thyroid cancer (DTC) treated with 131I.Aim: To evaluate the possibility of using L-T4 suppression treatment (Tg/L-T4) measurements by the ultrasensitive method TRACE (immunofluorescence method) with the KRYPTOR analyzer instead of the Tg/rhTSH measur...

There are growing evidences suggesting the existence of intra-tumor heterogeneity within the same patient, leading to a different genetic pattern between primary tumour and metastases.We report a paradigmatic example of genetic heterogeneity in thyroid cancer (TC). A 42 years old female patient was submitted, for a follicular TC, to total thyroidectomy and lymphadenectomy followed by radioiodine residue ablation in late 1999. In 2000 and 2001 diagnostic ...