ECE2016 Guided Posters Reproduction & Endocrine Disruption (10 abstracts)
Intima media thickness and brachial artery flow mediated dilatation in women with polycystic ovary syndrome and type 1 diabetes mellitus
Agnieszka Lebkowska 1 , Agnieszka Adamska 1 , Joanna Tolwinska 2 , Malgorzata Jacewicz 1 , Justyna Hryniewicka 1 , Robert Milewski 3 , Slawomir Wolczynski 4 , Artur Bossowski 2 , Maria Gorska 1 & Irina Kowalska 1
1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland; 2Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok, Poland; 3Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland; 4Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland.
Polycystic ovary syndrome (PCOS) and type 1 diabetes (T1DM) are accompanied by increased risk of atherosclerosis. A higher prevalence of PCOS in T1DM patients has been reported. Brachial artery flow-mediated dilatation (FMD) and intima media thickness of common carotid artery (IMT) are used to detect an early endothelial dysfunction.
The aim of our study was to examine IMT and FMD in T1DM women with PCOS. We also estimated the relation of IMT and FMD to clinical and hormonal parameters in the studied population.
We studied 85 women (mean age 25.1±4.3): 27 with T1DM (14 with PCOS+T1DM, 13 with T1DM/no-PCOS), 38 with PCOS and 20 healthy women (control group). IMT and FMD were assessed by ultrasonography. PCOS was diagnosed using the Rotterdam criteria. Clinical examination, lipid, hormonal profile and ultrasonographic evaluation of ovaries were performed for all women. In addition, concentrations of soluble E-selectin (sE-selectin) and intercellular adhesion cell molecule-1 (sICAM-1), as well as C-reactive protein (CRP) levels were assessed.
IMT and FMD did not differ between all studied groups. In patients with PCOS+T1DM, the median IMT value was 0.53 mm (IQR 0.44–0.54) and median FMD value was 12.66% (IQR 9.5–20.43). IMT was positively associated with BMI in the entire studied group and in patients with PCOS (r=0.357, P=0.001; r=0.342, P=0.036). IMT was also related to CRP, sE-selectin and sICAM-1 in the entire group (r=0.261, P=0.044; r=0.23, P=0.033; r=0.29, P=0.007). sE-selectin and sICAM-1 concentrations were higher in PCOS+T1DM than in PCOS group (P=0.002, P=0.006). In the T1DM group, we found FMD to be related to diabetes duration (r=−0.42, P=0.033). In the T1DM+PCOS patients, IMT was related to serum triglycerides (r=0.613, P=0.02) and to HDL-cholesterol (r=−0.524, P=0.055).
Our data suggest that early vascular changes in young T1DM patients are related to diabetes duration and additionally, in patients with PCOS+T1DM, to atherogenic lipid profile.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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