Endocrine Abstracts

Bisphenol A (BPA) is an environmental estrogen found in plastic material such as bottles, food package, dental material, etc. It is known to have many negative effects on human health and its exposure is associated with endocrine disorders including polycystic ovary syndrome (PCOS). Some studies found significantly higher serum and urinary levels of BPA in PCOS women, however its association with steroid hormones is still controversial.Aim: The aim of th...

Fludioxonil is an antifungal agent used in agricultural applications that is present at measurable amounts in fruits and vegetables. In this study, the effects of fludioxonil on cancer cell viability, epithelial-mesenchymal transition (EMT) and metastasis were examined in BG-1 ovarian cancer cells with estrogen receptors (ERs). BG-1 cells were cultured with 0.1% DMSO (control), 17β-estradiol (E2; 1×10−9 M), or fludioxonil (10−5&#8722...

Polycystic ovary syndrome (PCOS) is a significant risk factor for the development and progression of type I endometrial cancer (EC). Currently, it is not known whether metformin has a direct effect on the endometria and further regulates glycolysis and mitochondrial function in PCOS patients with endometrial hyperplasia and carcinoma. Here we show that endometria from PCOS patients with endometrial hyperplasia and carcinoma have a distinct protein expression pattern of glycoly...

Context: Betatrophin is a newly identified hormone appreciated for its role as a potent inducer of beta cell proliferation in line with insulin resistance in mice. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance. However, no evidence was available whether betatrophin is involved in women with PCOS.Objective: To ascertain whether betatrophin levels are altered in women with PCOS.<p class="...

Polycystic ovary syndrome (PCOS) and type 1 diabetes (T1DM) are accompanied by increased risk of atherosclerosis. A higher prevalence of PCOS in T1DM patients has been reported. Brachial artery flow-mediated dilatation (FMD) and intima media thickness of common carotid artery (IMT) are used to detect an early endothelial dysfunction.The aim of our study was to examine IMT and FMD in T1DM women with PCOS. We also estimated the relation of IMT and FMD to c...

Context: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of classic androgen synthesis. Recent work has highlighted that impaired DHEA sulfation results in enhanced androgen production. Here, we evaluated the relationship between DHEA and DHEAS and androgen excess and metabolic phenotype in PCOS.Patients and methods: We compared 65 women with PCOS to 35 healthy women matched for age and body mass index (BMI). All subject...

Introduction: Human Chorionic Gonadotropin (hCG) contributes to fetal tolerance by regulating innate and adaptive immune responses during pregnancy. Our previous results suggested a pregnancy protective effect of hCG through enhancement of regulatory T (Treg) cells and inhibition of dendritic cell (DC) maturation. Here, we aimed to investigate whether hCG contributes to Treg generation by modulating DC phenotype in vitro and in vivo in a murine model.<p c...

Background: Luteinizing hormone (LH) and choriogonadotropin (hCG) are glycoprotein hormones regulating ovarian function and pregnancy. They were routinely used in assisted reproduction techniques (ART) assuming they are equivalent, due to their binding to a common receptor (LHCGR). However, differences between LH and hCG were demonstrated at molecular and physiological level.Aim: The aim of this study is to evaluate how follicle-stimulating hormone (FSH)...

Background: The concept of testosterone (T) supplementation (TS) as a new anti-obesity medication in men with testosterone deficiency syndrome (TDS) is emerging.Aim: To systematically review and meta-analyze available observational and register studies reporting data on body composition in studies on TS in TDS.Methods: An extensive Medline Embase and Cochrane search was performed including the following words: ‘testosterone&#1...

Human 3β-hydroxysteroid dehydrogenase deficiency is a rare form of congenital adrenal hyperplasia resulting from HSD3B2 gene mutations, leading to steroidogenesis impairment in both adrenals and gonads. The transition period is important for a successful adult fertility, but information about fertility is lacking in this rare disease.The patient presented with salt wasting at birth in Trousseau Hospital. Consanguinity was present, since the parents ...