ECE2016 Guided Posters Receptors & Signalling (10 abstracts)
Increased 17beta-hydroxysteroid dehydrogenase type 1 mRNA level is correlated with poor prognosis in endometrial cancer
Karlijn Cornel 1 , Camilla Krakstad 2 , Balazs Jori 1 , Marlies Bongers 1 , Roy Kruitwagen 1 , Helga Salvesen 2 & Andrea Romano 1
1Maastricht University Medical Centre, Maastricht, The Netherlands; 2University of Bergen, Bergen, Norway.
Endometrial cancer (EC) is estrogen dependent and several enzymes control the local availability of these steroids by activating (i.e. aromatase, sulfatase, 17beta-hydroxysteroid dehydrogenase type 1 – HSD17B1) or deactivating estrogens (sulfotransferase, 17beta-hydroxysteroid dehydrogenase type 2 – HSD17B2). Imbalances in these enzymes are implied in EC development.
In the present study, it is evaluated whether imbalances in these enzymes are also associated with EC prognosis.
Tumour tissue collected directly after hysterectomy of 175 EC patients was included; 141 endometrioid (49 Grade I, 53 Grade II and 39 Grade III) and 34 non-endometrioid tumour types. Most tumours were estrogen receptor positive (72%). The mRNA levels of aromatase, sulfotransferase, sulfatase, HSD17B1 & HSD17B2 were measured using micro-array analyses. Patients were clustered according to the mRNA enzyme levels using quartiles.
It was observed that patients with high HSD17B1 mRNA levels (4th quartile) had a significantly poorer prognosis compared with patients with low HSD17B1 levels (1st, 2nd and 3th quartiles) (P=0.007). No significant correlation in the levels of HSD17B2, aromatase, sulfotransferase, sulfatase and patient prognosis was observed.
In conclusion, high HSD17B1 mRNA level, predicted to increase the availability of local estrogens, is correlated with poor prognosis in EC patients. Hence, HSD17B1 is a potential prognostic marker. Validation of these results in independent cohorts is required.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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