ECE2016 Guided Posters Paediatric Endocrinology & Development (10 abstracts)
Adrenal dysregulation in children who were born extremely premature – a pilot study
Carmen Campino 1, , Alejandro Martinez-Aguayo 2 , Rene Baudrand 2 , Cristian Carvajal 1, , Hernan Garcia 2 , Marlene Aglony 2 , Rodrigo Bancalari 2 , Lorena Garcia 3 , Carolina Loureiro 2 , Andrea Vecchiola 1, , Alejandra Tapia 1 , Carolina Valdivia 1, , Cristobal Fuentes 1 , Carlos Lagos 1, , Sandra Solari 4 , Fidel Allende 4 , Alexis Kalergis 5, & Carlos Fardella 1,
1Dpto Endocrinologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile; 2Division Pediatria, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile; 3Depto de Bioquimica and Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceticas, Universidad de Chile, Santiago, Chile; 4Depto de Laboratorios Clinicos, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile; 5Instituto Milenio de Inmunologia e Inmunoterapia, Santiago, Chile; 6Depto de Genetica Molecular and Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Introduction: The prevalence of hypertension in children and adolescent who were extremely preterm newborns (EP; ≤32 gestational weeks) has been found to be higher than in those born at term. The causes have not been well characterized. Studies support that adrenal dysregulation might be a consequence of prematurity.
Objectives: To determinate if children who were EP had higher adrenal hormones and vascular remodeling biomarker than term newborn (≥38 gestational weeks).
Design, subjects and methods: A pilot – cross sectional study was design. Children from the community were invited (n=235, range 5.1–15.5 years old); twelve were EP (gestational age between 30 and 32 weeks) and 223 were born at term (gestational age between 38 and 40 weeks). Anthropometric characteristics and aldosterone, plasma renin activity (PRA), aldosterone/PRA ratio (ARR), cortisol and cortisone were measured. Metalloproteinasa 2 (MMP-2) activity was measured as a vascular remodeling biomarker.
Results (median): Both groups were comparables in age (10.2 vs 11.6 years; P=0.075), BMI-SDS (1.13 vs 1.18; P=0.434), height-SDS (0.48 vs 0.23; P=0.434) and blood pressure corrected by gender, age and height (systolic index 1.09 vs 1.06, P=0.184 and diastolic index 1.11 vs 1.10 P=0.797). EP newborn vs term newborn showed similar aldosterone (ng/dl): 7.6 vs 6.2 (P=0.439) and PRA (ng/ml per h): 2.16 vs 2.3 (P=0.779) but higher ARR (3.9 vs 2.6 P=0.039) and higher MMP-2 activity (Arbitrary units): 1.88 vs 1.50 (P=0.009). No statistical differences in cortisol, cortisone and cortisol/cortisone ratio were observed.
Conclusions: This pilot study showed that children who were extremely preterm newborn have higher ARR and vascular remodeling than children born at term, despite similar blood pressure. Future studies to assess the importance of these findings in early prevention of hypertension are warranted.
Volume 41
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Endocrine Abstracts
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