ECE2016 Guided Posters Paediatric Endocrinology & Development (10 abstracts)
Association between urinary magnesium and glycaemic control in children and adolescents with type 1 diabetes mellitus
Filipe Cunha 1 , Juliana Oliveira 2 , Ana Saavedra 1 , Inês Alves 1 , Rita Santos-Silva 1 , Carla Costa 3 , Cíntia Castro-Correia 3 & Manuel Fontoura 3
1Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Porto, Portugal; 2Serviço de Pediatria do Centro Hospitalar de São João, Porto, Portugal; 3Unidade de Endocrinologia Pediátrica do Serviço de Pediatria do Centro Hospitalar de São João, Porto, Portugal.
Background: Hypomagnesemia is common in patients with diabetes; possibly due to higher renal magnesium excretion in those patients. Hypomagnesemia seems to correlate with poor glycaemic control. The relationship between urinary magnesium (UMg) and glycaemic control is not known. We aimed to study the association between UMg and glycaemic control in a type 1 diabetes (T1D) pediatric population.
Methods: Study of a pediatric population with T1D attending the Pediatric Endocrinology Clinic at Hospital de São João, Porto, between May 2014 and April 2015. We prospectively included all patients with UMg in a first-morning-void urine sample. Glycated haemoglobin (HbA1c) was measured in a capilar blood sample using DCA 2000 analyser. Patients with good and poor glycaemic control (cut-off used: 7.5%) were compared. We studied the correlation between UMg and HbA1c using Spearman’s rank correlation coefficient. A multivariate logistic regression model was built to study predictors of poor glycaemic control.
Results: We studied 48 patients. Mean age was 12±4 years and 58.3% were male. Mean duration of T1D was 88±43 months and mean HbA1c was 8.4±1.4%. Median (IQR) UMg was 8.46 (5.36–12.33) mEq/l. Twelve patients (25%) had good glycaemic control. Patients with good glycaemic control were more frequently on Continuous Subcutaneous Insulin Infusion (CSII) (7 (58.3%) vs 7 (19.4%); P=0.02) and had lower UMg (5.6 (3.1–7.7) vs 9.4 (6.8–12.4) mEq/l; P=0.01). There were no differences in serum magnesium levels. UMg had a weak positive correlation with HbA1c (ρ=0.30; P=0.04) and T1D duration (ρ=0.28; P=0.05). UMg was a predictor of poor glycaemic control OR: 1.40 (95% CI: 1.05–1.85), P=0.02; independent of age, T1D duration and CSII use.
Conclusions: UMg is an independent predictor of poor glycaemic control. Per each mEq/l increase of UMg there is a 40% higher risk of poor glycaemic control.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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