Endocrine Abstracts

Objective: Growth hormone (GH) replacement therapy currently requires daily injections. This may cause poor compliance, inconvenience and distress for patients. CTP-modified hGH (MOD-4023) has been developed for once-weekly administration in growth hormone deficient (GHD) adults and children. The 18 and 24 month efficacy of once-weekly subcutaneous (SC) administration of MOD-4023 was evaluated in a Phase 2 study in children with GH deficiency.Design and ...

Patients with congenital adrenal hyperplasia (CAH) require life-long, daily glucocorticoid hormone replacement therapy. Currently, there is no licensed treatment for young patients and existing treatment requires adapting adult doses by crushing tablets. As primary caregivers, parents of young children with CAH often take on the responsibility for routine medication and adapting doses in times of stress or illness. There has been little research to date exploring parents’...

Background: Dyshormonogenetic goiter and Hashimoto’s thyroiditis are amongst the commonest causes of hypothyroidism in children and adolescents Worldwide. But, the genetic basis and their hypothyroid phenotypes are under-reported, especially from developing countries. In this context, we screened for dyshormonogenetic mutations in hypothyroid children with dyshormogenetic goiter (DH) and Hashimoto’s thyroiditis (HT).Material and methods: In thi...

Background: Hypomagnesemia is common in patients with diabetes; possibly due to higher renal magnesium excretion in those patients. Hypomagnesemia seems to correlate with poor glycaemic control. The relationship between urinary magnesium (UMg) and glycaemic control is not known. We aimed to study the association between UMg and glycaemic control in a type 1 diabetes (T1D) pediatric population.Methods: Study of a pediatric population with T1D attending th...

Hyperandrogenism in adolescent girls is medical and social problem, including hirsutism, seborrhea, severe acne, alopecia and hyperclitoridism.Purpose: To study the frequency and clinical peculiarities of the hyperandrogenism (HA) in adolescent girls.Patients and methods: The study included 2369 girls (aged 11–19 years). Patients were subjected to the clinical examination, ultrasound examination. Index of hyperandrogenism (HAI...

A relationship between obesity, plasma leptin concentration and primary hyperparathyroidism has been previously reported. To test the hypothesis that leptin directly stimulates parathyroid hormone (PTH) secretion, in vivo and in vitro experiments were conducted. In the in vivo studies leptin (200 μg/kg, ip) was administered to lean and obese (mutants that do not express active leptin receptor) Zucker rats. The in vitro experiments were ...

Polycystic ovary syndrome (PCOS) is the most common cause of infertility in reproductive aged women affecting ~5–10% of women of reproductive age worldwide. PCOS patients are characterized by infertility disorders, obesity, insulin resistance and hyperandrogenemia that persists during pregnancy. This finding allowed to suggest the hypothesis that this intrauterine environment could affect the fetus, reprogramming the insulin sensitivity of the offspring. We have developed...

Background: In male to female transgender patients breast development is a key part in the process of feminization using cross sex hormone therapy. In the Endocrine Society’s clinical guideline ‘Endocrine treatment of transsexual persons’ the onset of breast growth is estimated as 3–6 months after starting cross sex hormone treatment. The maximum breast growth however is seen after 2–3 years. But how much growth, in centimeters or cup-sizes, we can exp...

Obesity epidemic is one of the major concerns in the world. Worryingly, a high percentage of pregnant women have obesity, which could imply several consequences. Maternal obesity leads to different abnormalities in pregnancy and delivery. In addition, recent studies show that the offspring of obese mothers has an increased probability to suffer cardiovascular, metabolic and reproductive diseases. We have previously demonstrated that exposure to a high fat diet is related to ob...

Introduction: The prevalence of hypertension in children and adolescent who were extremely preterm newborns (EP; ≤32 gestational weeks) has been found to be higher than in those born at term. The causes have not been well characterized. Studies support that adrenal dysregulation might be a consequence of prematurity.Objectives: To determinate if children who were EP had higher adrenal hormones and vascular remodeling biomarker than term newborn (&#...