Endocrine Abstracts

Type 1 diabetes mellitus (DM) is a multi system disease with both biochemical and anatomic/structural consequences. A number of components of the metabolic syndrome may be observed in patients with type 1 diabetes. It was suggested that treating obese adolescents with insulin resistance using metformin is an option for patients without response to traditional lifestyle change. It was reported that fetuin-A could inhibit insulin receptor tyrosine kinase activity and induced a l...

Objective: To study the GLP-1 pattern of secretion after an oral glucose tolerance test (OGTT) in women in postpartum reassessment of previous gestational diabetes (GDM). To evaluate clinical and laboratory parameters that can influence GLP-1 secretion.Patients and methods: Forty-eight women with a history of GDM were assessed one year after childbirth determining clinical and analytical characteristics and OGTT with 75 g. We measured glucose, insulin an...

Background: Resistin is a hormone that potentially links obesity to T2DM. Several single nucleotide polymorphisms (SNPs) have been identified in the resistin gene (RETN). Polymorphism of RETN +299 (G>A) may contribute to increased resistin levels, which may be involved in the pathogenesis of T2DM.Aim of work: To study the association between resistin gene +299 polymorphism and insulin resistance in non-diabetic offspring of T2DM.<p class="abstext...

Objective: Gestational diabetes mellitus (GDM) is a multifactorial disorder with environmental factors and genetic modifiers. IGF2BP2 gene polymorphisms are shown to be involved in T2DM and diabetic nephropathy. Here, we aimed to document the association between IGF2BP2 gene polymorphism and GDM to understand the pathogenesis of GDM.Design: Matched, case-control study.Method: Ninety-three patients with GDM and 89 healthy pregnant s...

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Red blood cell (RBC) deformability is an ability of RBC to change shape under stress, and it has been known to be decreased in diabetes. However, the role of RBC deformability is not determined in type 2 diabetes (T2D) yet. We attempted to clarify whether RBC deformability is related with diabetic complications. This was a cross-sectional study, and 452 T2D patients were enrolled. RBC deformability was measured by using a microfluidic ektacytometer, Rheoscan-D (Rheo-Meditech, ...

Background and aims: Microalbuminuria (MA) is not specific predictor of early stages of chronic kidney disease (CKD) in diabetes. We investigate several markers that might be useful in assessing early kidney damage in T1DM and T2DM patients additional to MA.Materials and methods: We examined 111 patients (T1DM/T2DM: 51/60) with AER<20 mg/l (n=80); <199 mg/l (n=18); ≥200 mg/l (n=13). Biomarkers of kidney damage (c...

Introduction: The purpose was to compare aqueous inflammatory and angiogenic cytokine levels in diabetic macular edema (DME).Methods: Aqueous samples were obtained from 50 eyes with DME and 12 normal eyes (control group). DME was classified according to the morphologic pattern based on optical coherence tomography: Diffuse retinal thickening (DRT; n=19), cystoid macular edema (CME; n=17), or serous retinal detachment (SRD; n=14...

Introduction: Type 1 diabetes mellitus (T1DM) is associated with reduced bone mineral density (BMD) and increased bone turnover. However, data regarding the influence of glycemic control on bone are limited. The aim of this study was to evaluate BMD and bone remodeling markers in patients with T1DM in relation to changes in glycemic control.Methods/design: We studied 107 patients with T1DM (Group-D) (mean age: 34+8.1 years, M/F: 48/59) and 95 healthy con...

Introduction: Diabetes mellitus (DM) is a common chronic metabolic disease associated with serious complications. Diabetic retinopathy (DR) is one of the most common microvascular complications of DM. The aim of this study was to investigate the association between DR and dyslipidemiaMethods: A total of 1363 subjects were included in this retrospective study. The participants were divided into three groups, including a study group of 352 patients with di...