Endocrine Abstracts

Introduction: Hypercholesterolemia is frequently found in patients with type 2 diabetes (T2D). Cholesterol is metabolized from 7-dehydrocholesterol by 7-dehydrocholesterol reductase (DHCR7) from 7-dehydrocholesterol, a precursor of pre-vitamin D3. Therefore single nucleotide polymorphisms (SNP) in the DHCR7 gene could regulate cholesterol levels and concentrations of vitamin D metabolites (25(OH)D3 or 1,25(OH)2D3). For this purpose we investiga...

Aim: We assessed in both men and women within different BMI- and age classes the prevalence of MetS and its individual components, since these specific estimates obtained simultaneously in a large western European population are lacking. Secondly, we measured as well how age-specific blood pressure (BP) cut-offs affect the prevalence of elevated BP and MetS.Methods: Data of 74 531 western European participants, aged 18–79 years, were obtained from t...

Introduction: Olfactory and gustatory dysfunction in patient with diabetes mellitus (DM) and its pathophysiology were studied in many previous studies. Some studies reported that there was a relationship between type 1 DM (T1DM) and olfactory and gustatory functions the presence of diabetic complications. However findings are limited and controversial. The aim of this study was to determine the relationship between olfactory and gustatory scores and patients with non-complicat...

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Introduction: Berardinelli Seip Congenital Lypodystrophy (BSCL) is a rare otosomal recessive disease characterized by major criteria which are lypoatrophy, acromegaloid features, hepatomegaly, hypertriglyceridemia, insulin resistance and minor citeria which are hypertrophic cardiomyopathy, psycomotor retardation, hirsutism, precocious puberty, long bone cysts, phlebomegaly. The presence of three major criteria or two major plus two minor criteria required for diagnosis of BSCL...

Introduction: Proinsulin is a propeptide of insulin and C-peptide during physiological insulin production and is increased in patients with type 2 diabetes. Increased proinsulin in peripheral blood indicates impairment of cleavage capacity to process insulin within the beta cell. Recently, chemiluminescence assays have been developed that are able to specifically measure uncleaved intact proinsulin in peripheral blood. In this cross-sectional study, we investigated the relatio...

Background and aims: The mechanisms underlying placenta oxidative stress co-existing with alterations in maternal-placenta interactions during gestational diabetes mellitus (GDM) are not well understood. We sought to evaluate the levels of oxidative stress markers and antioxidants in women with GDM, and to assess the impact on placenta.Material and methods: Pregnant women (63 with GDM, 63 controls) were enrolled, together with 41 cases and 21 controls fo...

Background: Studies have shown that smoking may increase the risk of pancreatic disorders. This study aimed to evaluate the oxidative stress status, biochemical, pathological and immunohistochemical findings of rats exposed to the cigarette smoke, pathogenesis of smoking related pancreatic damage and usability of Alpha Lipoic Acid (ALA) for amelioration of cigarette’ harmful effects on rat pancreas.Methods: Twenty eight female, Sprague Dawley rats w...

Objectives: High-fructose corn syrup (HFSC) is used as an artificial sweetener. However, there is limited information about the metabolic effects. Fructose is implicated in the etiology of nonalcoholic fatty liver disease(NAFLD). Unfortunately, no therapy for NAFLD currently exists. The aim of this study was to investigate the hepatic lesion induced by chronic HFCS consumption and the protective effects of alpha-lipoic acid (ALA) on hepatic pathology.Met...

Introduction: The microvascular complications of diabetes and consequent autonomic neuropathy may cause changes in saliva’s secretion and composition. Hyperglycemic levels can also contribute to various oral pathological changes due to alteration of fungi or bacterial flora and dental biofilm surface, leading to the onset of candidiasis, periodontitis and dental caries. The aim of this study was to determine total bacterial load of saliva and dental biofilm of diabetic pa...