Endocrine Abstracts

Introduction: Insulinomas are the most frequent cause of endogenous hypoglycaemia. 90 to 95% of these are benign. Surgical enucleation or resection is the standard treatment. Medical therapy focuses mainly on the use of diazoxide with few alternatives in patients with high surgical risk.Case-report: Female patient, 89 years-old, non-diabetic, with previous history of acute myocardial infarction, stroke with motor sequelae, pacemaker carrier and severe ao...

Introduction: Hormone-secreting teratomas are well described. However teratomas secreting pancreatic hormones are rare, with even fewer cases producing clinically significant effects. We describe possibly the first documented case of hyperinsulinaemic hypoglycaemia due to an insulin-secreting ovarian teratoma.Case report: A 23-year-old woman presented with transient symptoms of lethargy and weakness. She had used her father’s capillary glucose meter...

Introduction: Severe insulin resistance syndromes are rare syndromes characterized by clinical features like: acanthosis nigricans, ovarian hyper androgenism in post pubertal females: hirsuitism, oligomenorrhea and infertility.Major causes of severe insulin resistance are: i) genetic defects in insulin receptor like type A syndrome, or ii) autoimmune like antibodies to insulin receptor like in type B syndrome or antibodies to insulin itself, iii) congeni...

Introduction: Premature ovarian insufficiency is characterized by precocious depletion of ovarian follicles, associated with amenorrhea, hypoestrogenism and high gonadotropin levels. It afflicts 1% of the female population and in 5% cases it is due to X chromosome abnormalities.Case report: A 22 year old previously healthy female, presented to the Endocrinology Clinic due to amenorrhea. She had no family history of amenorrhea, her menarche was at age 11 ...

Introduction: Pseudohypoparathyroidism (PHP) refers to a group of rare sporadic or inherited disorders characterized by parathyroid hormone (PTH) resistance. We report a case of PHP with phenotypical expression and multiple hormonal resistance.Case description: We report a 26-year-old lady who presented to us after a fall, with history of recurrent seizures since 12 years of age. There was a history of oligomennorhoea. Physical examination revealed round...

Introduction: Abnormalities in liver biochemistry are frequent in Turner’s syndrome (TS) with a reported prevalence between 20 and 80%. While their aetiology remains unclear, metabolic factors and intrahepatic biliary disease have been postulated. Moreover, some TS patients have a predominantly cholestatic biochemical abnormality and others a hepatitic picture. Ursodeoxycholic acid (UDCA) has been shown to be a useful treatment of cholestatic disease.<p class="abstext...

Clinical case: We report the case of a 40-year-old woman, diagnosed with sporadic medullary thyroid carcinoma (MTC) treated with total thyroidectomy, cervical lymph node dissection and chemotherapy. During follow-up, cervical lymph node, lung, breast, bone and subcentimeter cerebellous affectation was observed. She started on Sunitinib, but withdrawal at 6 months due to severe inguinal inverse psoriasis. Then, treatment with vandetanib was started with good response. Tumor mar...

Nivolumab is the first programmed death 1 (PD-1) immune checkpoint inhibitor. It is approved for use in advanced melanoma and squamous non small cell lung cancer (NSCLC). PD-1 immune checkpoint inhibitors can cause autoimmune disease of endocrine glands, including the thyroid. Here, we present a case of thyroiditis after nivolumab therapy.A 61 year-old female patient with NSCLC was consulted to endocrinology department for abnormal thyroid function test ...

Introduction: Autoimmune polyglandular syndrome type 1 (APS1) – severe disease that is rare in pediatric practice. Clinical sings of APS1 are quite diverse, new components may manifest at any age. Their timely diagnosis is critically important, some symptoms can threaten patient’s life. We present our own clinical observation of the APS1 course in siblings.Case report: A 10-year-old previously healthy boy presented with severe weakness, drowsin...

Introduction: Despite recommendations neuroendocrine tumors may still pose diagnostic and therapeutic problems. Patients are referred to specialized centers when their disease has already progressed to generalized stage.Case report: A 64-year old male patient was referred to the Department of Endocrinology at the Pomeranian Medical University in 2013 because of liver metastases. His medical history included a surgical treatment of left lung tumor in 2006...