ECE2016 Guided Posters Adrenal (2) (10 abstracts)
Clinical characteristics and tumour size evolution in patients with bilateral adrenal tumours
Simona Galoiu 1, , Raluca Pena 1 , Raluca Trifanescu 1, , Dan Alexandru Niculescu 1, , Anda Dumitrascu 2 , Andra Caragheorgheopol 2 , Carmen Iordachescu 2 & Catalina Poiana 1,
1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2C. I. Parhon National Institute of Endocrinology, Bucharest, Romania.
10% of patients with adrenal tumours have bilateral lesion.
Objective: To evaluate clinical, imagistic and hormonal characteristics of bilateral adrenal tumours.
Design and mehods: Retrospective series of 150 consecutive patients (104F, 46M) with bilateral adrenal tumours with maximal diameter of at least 1 cm, evaluated from 2001 to 2015 in a tertiary endocrinology clinic with clinical, hormonal and imagistic methods.
Results: Age at diagnostic was 57.26±10.32 years (27–85). In 122 patients, adrenal tumours were diagnosed simultaneously, and 28 patients had metachronous tumours. Mean tumor size was 2.4±2.3 cm (right) and 2.5±2.4 cm (left). 22% patients had functioning tumours (22 patients with cortisol hypersecretion, including subclinical Cushing’s syndrome, eight patients with pheocromocitoma, three patients with aldosterone hypersecretion). Four patients had adrenal carcinoma and ten patients adrenal bilateral metastasis. Clinical evaluation revealed younger age (44.90±12.98 years) in patients with pheocromocitoma and higher blood glucose (123.75±52.26 mg/dl vs 103.34±26.62 mg/dl, P=0.03) and tumor diameters (3.48±2.22 cm vs 2.23±2.42 cm, P=0.02 – right side and 3.86±2.23 cm vs 2.31±2.43 cm, P=0.007 – left side) in patients with cortisol secreting tumours as compared to patients with nonfunctioning tumours. Mean follow-up was 1.84±0.89 years in patients with synchronous tumours; in patients with metachronous tumours, second tumour was diagnosed after 5.44±9.37 years (maximum 49 years). In nonoperated nonfunctioning tumours, nonsignificant tumour size evolution was observed.
Conclusion: Our study suggests cortisol hypersecretion is the most frequent hormonal abnormality in patients with bilateral adrenal tumours. Although most nonfunctioning tumours are nonevolutive, as 9.3% of patients have primary or secondary adrenal cancer, conservative long-term follow up is needed.
Volume 41
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