ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Evaluation of TSH receptor antibodies and histopathological features in patients with toxic multinodular and toxic nodular goiter
Cevdet Aydin 1 , Husniye Baser 2 , Fatma Neslihan Cuhaci 1 , Didem Ozdemir 1 , Samet Yalcin 3 , Reyhan Ersoy 1 & Bekir Cakir 1
1Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey; 2Ataturk Education and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey; 3Yildirim Beyazit University Faculty of Medicine, Department of General Surgery, Ankara, Turkey.
Introduction: Association between high thyrotrophin receptor antibodies (TRAb) and relapse of thyroid cancer in Graves’ patients was reported previously. In this study, we aimed to investigate possible relation between TRAb and thyroid malignancies in patients with toxic multinodular (TMNG) and toxic nodular goiter (TNG).
Methods: Thyroidectomized patients with a preoperative diagnosis of TMNG, TNG and euthyroid multinodular or nodular goiter (MNG/NG) were retrospectively recruited for the study. Preoperative TRAb measurements were available in 221 patients with TMNG/TNG and 43 patients with euthyroid MNG/NG. Results were compared in these two groups.
Results: Histopathology was malignant in 71 (32.1%) and benign in 150 (67.9%) of TMNG/TNG patients. In euthyroid group, malignancy was observed in 18 (41.9%) and benign histopathology was observed in 25 (58.1%) patients. In TMNG/TNG group, TRAb was positive in 7 (9.9%) patients with malignant and 17 (11.3%) patients with benign histopathology (P=0.742). In euthyroid group, TRAb was positive in 1 (5.6%) patient with malignant and 2 (8.0%) patients with benign histopathology (P=0.756). TRAb positivity did not change between TMNG/TNG and euthyroid patients with malignant and benign histopathology (P=0.569 and P=0.620, respectively).
Conclusion: TRAb positivity seems to have no effect on malignant histopathology in patients with TMNG and TNG. Limited number of cases and lack of TRAb measurement in all TMNG/TNG patients undergoing thyroidectomy might contribute to this finding.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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