ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Factors associated with persistent atrial fibrillation after achievement of euthyroid state
Amel Melki 1 , Meriem Yazidi 2 , Ines Barka 3 , Fatma Chaker 4 , Mélika Chihaoui 5 , Ons Rjeb 6 & Hédia Slimane 7
1Department of Endocrinology, La Rabta Hospital, Tunis, Tunisia; 2Department of Endocrinology, La Rabta Hospital, Tunis, Tunisia; 3Department of Endocrinology, La Rabta Hospital, Tunis, Tunisia; 4Department of Endocrinology, La Rabta Hospital, Tunis, Tunisia; 5Department of Endocrinology, La Rabta Hospital, Tunis, Tunisia; 6Department of Endocrinology, La Rabta Hospital, Tunis, Tunisia; 7Department of Endocrinology, La Rabta Hospital, Tunis, Tunisia.
Introduction: Atrial fibrillation (AF) occurs in up to 15% of patients with hyperthyroidism. Although hyperthyroidism is usually regarded as a reversible cause of AF, spontaneous sinus conversion occurs in only 2/3 of patients upon the normalization of T4 levels. The aim of this study was to identify factors associated with persistent atrial fibrillation after restoration of euthyroid state.
Methods: We conducted a retrospective study of 13 years. Twenty patients hospitalized for hyperthyroidism with AF and who had normalized their FT4 level during follow-up were enrolled. Non parametric Mann Whitney test was used to compare medians.
Results: The median follow-up period was 58 months. At the end of the follow-up period, 6 patients were euthyroid, 13 hypothyroid and 1 patient had a subclinical hyperthyroidism. Eight of the 20 patients returned to sinus rhythm after a median of 15 months. We found no significant difference between subjects who returned to sinus rhythm and those with persistent AF in terms of age (55.3±18.6 vs 55.9±12.3 years, P=1), gender (58.3% vs 41.7% men, P=0.65), history of hypertension (25% vs 25%, P=1), history of diabetes (12.5% vs 16.7%, P=1), abnormal echocardiography (33.3% vs 10%, P=0.51), the value of the ejection fraction (55.1±13.2% vs 59.0±5.0, P=0.71), toxic nodular etiology of hyperthyroidism (16.7% vs 83.3%, P=0.33), the value of the initial FT4 level (3.5±0.8 vs 5.1±5.1 ng/dl, P=0.77) and the period between the diagnosis of hyperthyroidism and the normalization of FT4 level (29.1±48.2 vs 31.9±27.6 months, P=0.17).
Conclusion: Successful treatment of hyperthyroidism resulted in conversion from atrial fibrillation in up to one third of our patients. No factors were associated with persistent atrial fibrillation in our study.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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