ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Hoffmann syndrome: a case report
Ines Barka , Amel Maaroufi , Wafa Badr , Yosra Hasni , Maha Kacem , Molka Chadli Chaieb & Koussay Ach
Endocrinology Department, Farhat Hached University Hospital, Sousse, Tunisia.
Background: Hoffmann syndrome is a rare form of hypothyroid myopathy in adults characterized by presence of muscle weakness, stiffness and pseudo-hypertrophy. Here, we report a case of Hoffman syndrome aggravated by statin therapy.
Case report: We describe the case of a 60 year old woman with primary hypothyroidism who presented with fatigue, cold intolerance, constipation, exertional breathlessness, progressive proximal muscle weakness and swelling of the legs for 3 months. She had a history of coronary heart disease treated by statin therapy. Examination revealed pseudo-hypertrophy of calf muscles with marked symmetrical proximal upper and lower limb weakness. The electrocardigram revealed an atrial fibrillation.
Her TSH and Creatine phosphokinase (CPK) levels were significantly elevated. Following institution of replacement therapy with thyroxine, the patient showed marked clinical and biochemical improvements after six months, but insignificant decrease in muscle mass.
Conclusion: Hoffman syndrome is a very rare form of hypothyroid myopathy seen in adults with longstanding untreated hypothyroidism. seen in adults with long standing untreated hypothyroidism.
The diagnosis should be suspected when a patient with calf muscle hypertrophy is also treated by statin therapy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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