Endocrine Abstracts

Abstract

Aim and objectives: To investigate the prevalence of relationships between kin/relatives with a known thyroid immune disorder related to Hashimoto thyroiditis.

Material and method: 1. Thyroid disease diagnosis: a. ATPO > 34 u/ml = Hashimoto thyroiditis (HT); b. ATPO = normal but with high antithyroglobuline (ATG) = thyroiditis with only hyper-ATG (T-ATG); c. hypothyroidism without high ATPO/ATG = idiopathic mixedema (IM).

2. Searching for a relationships between kins (including anamnesis).

Results: There were registered 1401 pt with HT, 129 T-ATG, and 108 Idiopathic myxedema. A specific kin/relationship could be identified in 189 patients. The distribution was tabulated.

1. Mother-Daughter: Pairs: 74, 6, 5; Total: 86.

2. Mother-Son: Pairs: 12, 1, 0; Total=16;

3. Father-Daughter: Pairs: 8, 0, 0; Total=8

4. Father-Son: Pairs: 3, 0, 0. Total=3.

5. Grandmother-Grandson/daughter: Pairs=1, 0, 0; Total=1.

6. Uncle/Aunt-Nephew: Pairs: 4, 1, 0; Total=5.

7. Wife-Husband: Pairs: 4, 0, 1. Total=5.

8. Sister-Sister: Pairs: 19, 2, 3. Total=24.

9. Sister-Brother: Pairs: 5, 0, 0. Total=5

10. Total pairs: 130, 10, 9.

11. Multiple members: 5, 0, 0.

12. Patients: 197, 16, 17. Percent: 11.28, for HT; 12.4, for TATG; 15.74 for Idiopathic Myxedema.

The presence of a relationship between kin could be registered in 11.28% from patients with Hashimoto thyroiditis, in 12.4% from those with only T-ATG and 15.74% from those with idiopathic myxedema.

Conclusion: Therefore, the penetration of a relationship between two kin with Hashimoto thyroiditis and related disorders could be registered in over 13% patients (more exactly, 13.17%).