ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Is the high mean platelet volume associated with inflammation in subacute thyroiditis?
Eda Simsek 1 , Faruk Yildiz 2 , Esra Ademoglu 3 , Senay Arikan Durmaz 4 , Murat Filiz 2 , Fatih Bingöl 1 , Buket Bingöl 1 , Emine Kartal Baykan 2 , Unsal Aydin 2 , Ahmet Veli Sanibas 2 & Ayse Carlioglu 2
1Department of Ear, Nose and Throat, Erzurum Region Education and Research Hospital, Erzurum, Turkey; 2Department of Endocrinology, Erzurum Region Education and Research Hospital, Erzurum, Turkey; 3Department of Endocrinology and Metabolism, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey; 4Department of Endocrinology and Metabolism, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
Introduction and aims: Subacute thyroiditis (ST) is a spontaneous remitting inflammatory disease of thyroid gland. Although there is no clear evidence for its specific etiology, multiple factors may responsible for this inflammatory reaction. Mean platelet volume (MPV) is a new important inflammatory marker that indicates disease activity. Aim of this study is to evaluate MPV value in patients with subacute thyroiditis.
Materials and methods: Thirty-one patients with subacute thyroiditis [mean age 42.55±11.59 years; body mass index (BMI) 26.64±1.33 kg/m2] and 52 age- and BMI-matched control subjects (mean age 37.34±17.81 years, BMI 25.45±6.76 kg/m2) were included our study. All blood samples in patients with ST were taken at diagnosis. The MPV was measured in a blood sample collected in Edta. The Beckman Coulter LH 750 (impedance method) analyzer was used for complete blood counts.
Results: At diagnosis, the mean FT3 levels were 4.34±2.86 pg/ml; FT4 levels were 1.61±1.01 pg/dl; TSH levels in ST were 0.31±0.35 μIU/ml (median 0.16; minimum level 0.001-maximum level 1 μIU/Ml) whereas the mean FT3 levels were 4.47±3.53 pg/ml; FT4 levels were 1.32±0.65 pg/dl; TSH levels in control were 1.58±0.99 (median 1.3; minimum 0.4-maximum 4.6) μIU/ml, P<0.001. ESR in ST were higher than control (mean ESR 41.04±36.19 in ST group vs. 13.24±13.26 mm/hour in control, P<0.001). However, CRP and white blood cell count in ST did not find statistically different from control. More importantly, the MPV was significantly higher in ST group than healthy control (8.79±1.23 and 7.62±0.75 fL, respectively; P<0.0001). MPV had positive correlations between CRP (r=0.414; P=0.013) and ESR (r=0.74; P=0.001). There was a negative correlation between MPV and TSH (r=−0.288; P=0.017).
Conclusions: According to our knowledge, we demonstrated first time that high MPV value was associated with subacute thyroiditis. MPV may be a new valuable marker of disease activity of ST as much as high ESR value.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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