Endocrine Abstracts

Levels of thyroid hormones may effect the levels of the glycation product and those of the oxidation products.

Objective: To evaluate the relationship between skin autofluorescence (SAF), and serum advanced glycation end products (AGEs) parameters in hypothyroid and hyperthyroid patients.

Method: Newlydiagnosed or untreated 100 overt and subclinical hypothyroid patients (42±13 yrs) and 50 overt-subclinical hyperthyroid patients (46±13 yrs) and 50 control subjects (47±10 yrs) were enrolled after excluding diabetes. Serum carboxymethyllysine (CML) and receptor for advanced glycation end products (sRAGE) levels were measured with ELİZA. TSH and fT4 measured Skin autofluorescence (SAF), a noninvasive measurement method, reflects tissue accumulation of AGEs. Skin AF was measured using the AGE-Reader (DiagnOptics B.V., Groningen, The Netherlands).

Results: SAF measurements were 1.82±0.04, 1.63±0.3, 1.80±0.4 arbitrary Units (AU) for hypothyroid, euthyroid and hyperthyroid groups respectively (P=0.04) Serum CML levels were 8.2±2.8 ng/ml, 8.0±3.3 ng/ml and 10.2 ng/ml for hypothyroid, euthyroid and hyperthyroid groups respectively (P=0.01). sRAGE levels were similar between the groups. TSH and SAF was positively correlated (r=0.25, P=0.02) in hypothyroid group while showed a negative correlation in hyperthyroid group (r=−0.36, P=0.04). There was no correaliton between CML and sRAGE levels and SAF.

Conclusion: Accumulation of skin AGEs is increased in hypothyroid and hyperthyroid patients compared to euthyroid subjects. Thyroid status may modulates glycoxidative and Modification of tissue proteins. Although longitudinal studies needed, SAF measurement, as a noninvasive method, may be useful for identification of clinical risk factors in hypo and hyperthyroid patients