ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Thyroid function parameters in Polish pregnant women
Malgorzata Trofimiuk-Müldner 1, , Zbigniew Szybinski 4 , Grzegorz Sokolowski 2 , Agnieszka Stefanska 2 , Monika Buziak-Bereza 1, , Zbigniew Adamczewski 3 , Andrzej Lewinski 3 & Alicja Hubalewska-Dydejczyk 1,
1Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland; 2Department of Endocirnology, University Hospital in Krakow, Krakow, Poland; 3Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland; 4Polish Council for Control of Iodine Deficiency Disorders, Krakow, Poland.
Thyroid function in pregnancy differs between populations. The aim of the study was to assess thyroid parameters in Polish pregnant women. It included 1095 pregnant volunteers aged 16–42 years (174, 501, 420 in the 1st, 2nd, and 3rd trimester, respectively), who gave their informed written consent. In each woman thyroid ultrasound was performed, 90.7% had TSH, fT4 and a-TPO measured, and 84.0% iodine urinary concentration (UIC) in urine spot sample estimated.
Results: Median UIC in study group was 92.3 μg/l. UIC above 150 μg/l was noted in 22.3% of women. Median, 2.5 and 97.5 percentile for TSH were 1.6, 0.13 and 4.97 mIU/l, respectively; for fT4 12.3, 8.72 and 17.92, respectively; for a-TPO 10.7, 8 and 16.4 IU/l, respectively. 88.6% of women were a-TPO. Median, 2.5 and 97.5 percentile for TSH in those subjects were 1.57, 0.10 and 4.76 mIU/l, respectively. Median, 2.5 and 97.5 percentile for TSH in the 1st trimester were 1.18, 0.029 and 6.08 mIU/l, respectively; in the 2nd trimester: 1.71, 0.22 and 4.87 mIU/l, respectively; in the 3rd trimester: 1.60, 0.35 and 4.97 mIU/l, respectively. TSH level ≥ 2.5 mIU/l was observed in 19.1% of women in the 1st trimester, and TSH ≥ 3 mIU/l – in 13.9% in the 2nd or 3rd trimester. Median, LQ and UQ for thyroid volume were 12.05, 9.44 and 15.07 ml, respectively. Thyroid nodules were noted in 21.1% of women, thyroid nodules > 1 cm – in 6.6%.
Conclusions: The study indicated that in iodine deficient pregnant women TSH levels are higher than recommended by current guidelines. The adequate iodine supplementation should be provided, and the threshold for L-thyroxin treatment implementation in such population should be revised.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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