ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Soluble (Pro)rennin receptor levels in patients with graves disease
Yuki Mizuguchi , Midori Yatabe , Junichi Yatabe , Yasufumi Seki , Michita Niyama , Kanako Bokuda , Daisuke Watabnabw , Takashi Ando , Satoshi Morimoto & Atsuhiro Ichihara
Tokyo Women’s Medical University, Department of Medicine II, Endocrinology and Hypertension, Tokyo, Japan.
Background: (Pro)renin receptor[(P)RR] is a multi-functioning transmembrane protein which plays key roles in the regulation of tissue renin-angiotensin system (RAS). (P)RR is cleaved by furin to generate soluble (P)RR[s(P)RR], which is secreted into extracellular space. We previously reported that high blood concentration of s(P)RR indicates poor organ prognosis in several diseases. In this way, s(P)RR is expected as a candidate biomarker for reflecting the tissue RAS status, but its regulating factor remains unclear. We also reported the positive relationship between serum s(P)RR concentration and thyroid function in hypertensive patients, which suggests that the enhanced metabolism might regulate the synthesis of s(P)RR.
Methods: We measured serum s(P)RR concentration in untreated patients with Graves disease (GD, n=52), hashimoto disease (n=23), acromegary (n=11) and pheochromocytoma (n=15). We also assessed the relationship between background factor associated with endocrine disease and serum s(P)RR levels.
Results: In patients with GD, serum s(P)RR levels (27.51±0.75 ng/ml) were significantly higher than the levels of normal subject (21.94±0.29 ng/ml). There was no significant change of s(P)RR levels in other endocrine disease patients. The GD patients with low BMI (≤22 kg/m2) showed higher levels of serum s(P)RR, while serum s(P)RR levels was positively correlated with BMI in normal subject. The GD patients with high level of s(P)RR (>27 ng/ml) showed treatment-resistant against medication (RR=2.62).
Conclusion: Serum s(P)RR levels were significantly high in GD patients with low BMI and high levels of serum s(P)RR levels predict a resistance for medication. These results suggests that poor nutritional condition caused by the excess of thyroid hormone may stimulate the s(P)RR production, leading to the RAS-related organ damage.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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