ECE2016 Eposter Presentations Thyroid cancer (81 abstracts)
Can we predict malignancy in AUS/FLUS by measuring TSH?
Ricardo Rodrigues Marques 1 , Ana Alves Rafael 1 , Francisco Sousa Santos 2 , Silvia Sofia Silva 1 , João Sequeira Duarte 2 & Luís Viana Fernandes 1
1CHLO, EPE - Hospital Egas Moniz - Department Cirurgia II, Lisboa, Portugal; 2CHLO, EPE - Hospital Egas Moniz - Department Endocrinologia, Lisboa, Portugal.
Background: Fine-needle aspiration (FNA) is an important test for triaging patients with thyroid nodules and differentiating benign from malignant disease. According to Bethesda System Classification, the rate of AUS/FLUS is between 3–6% of all FNA. The malignancy risk is of 5–15%. TSH levels might be associated to the likelihood of malignancy in thyroid nodules according to some studies. Our aim was to establish a possible correlation between TSH level and malignancy of AUS/FLUS.
Methods: Retrospective study using SPSS.
Results: The authors reviewed a total of 2891 patients from January 2012 to December 2014. There were 564 (15.9%) AUS/FLUS in 3557 thyroid FNAs performed. The malignancy risk was 9.6%. The rate of carcinomas on operated patients was 30%. From a total of 180 performed surgeries, there were 54 carcinomas. TSH value was determined in carcinomas. 11 were excluded because of missing data or because of patients under thyroid hormonal replacement before surgery. On the 43 remaining patients correlation between AUS/FLUS and TSH values was established. The mean value for TSH in carcinomas versus control group (benign lesions) was 1.74 vs 1.45 (P value =0.117).
Conclusion: We could not establish a correlation between TSH level and the likelihood of carcinomas in AUS/FLUS in our series. A bigger data may be necessary to get statistically significant results.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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