ECE2016 Eposter Presentations Thyroid cancer (81 abstracts)
Coexisting papillary thyroid carcinoma and renal cell carcinoma: 4 cases
Mehmet Celik 1 , Semra Ayturk 1 , Buket Yilmaz Bulbul 1 , Nuray Can 2 , Ebru Tastekin 2 , Atakan Sezer 3 , Funda Ustun 4 & Sibel Guldiken 1
1Trakya University Medical Faculty, Department of Endocrinology and Metabolizm, Edirne, Turkey; 2Trakya University Medical Faculty, Department of Pathology, Edirne, Turkey; 3Trakya University Medical Faculty, Department of Surgery, Edirne, Turkey; 4Trakya University Medical Faculty, Department of Nuclear Medicine, Edirne, Turkey.
Papillary thyroid cancer (PTC) constitutes 85% of all differentiated thyroid cancers. PTC is usually sporadic, but may occur in a familial form. Familial cancer syndromes such as Cowden’s syndrome and familial adenomatous polyposis are associated with PTC. Lal et al. recently published a study in which subsequent thyroid cancer was most common among the patients with renal cell cancer (RCC). RCC is a common malignancy of uroepithelial region, which constitutes about 3% of all adult malignancies. We presented 4 cases consecutively diagnosed with PTC and RCC within 12 months (Table). 3 cases with BRAF positivity had lymph node metastasis. The BRAF gene is located on chromosome 7. BRAF is a signaling protein downstream of Ras that activates the MAP-kinase pathway and implicated in cell differentiation and proliferation. Mutations of this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, PTC and lung carcinoma, while few studies reported RCC cases with BRAF mutation. In 2016, Natasha Banerjee et al. reported a case with metastatic RCC and BRAF mutation, in whom a good clinical outcome was achieved following BRAF inhibition. BRAF positivity observed in 3 of our cases suggests that further studies are required on a common mutation that exists in RCC and PTC.
| CASE 1 | CASE 2 | CASE 3 | CASE 4 | |
| Age | 64 | 48 | 56 | 67 |
| Gender | Male | Male | Male | Male |
| Clinic | Euthyroid | Euthyroid | Hyperthyroid | Hyperthyroid |
| PTC-variant | Classic and follicular | Classic and follicular | Classic and oncocytic | Classic, follicular and oncocytic |
| PTC-grade | pT1a –pN1 | pT1a –pNx | pT3a –pN1 | pT4a –pN1 |
| Focality | Multifocal | Multifocal | Multifocal | Multifocal |
| Metastasis | + | − | + | + |
| BRAF mutation | V600E (+) | Not analyzed | V600E (+) | V600E (+) |
| RAI (I-131) | + | − | + | + |
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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