ECE2016 Eposter Presentations Thyroid cancer (81 abstracts)
Can ratio of primary tumor diameter to total tumor diameter be a new parameter in the differential diagnosis of agressive and favorable multifocal papillary thyroid microcarcinoma?
Abbas Ali Tam 1 , Didem Ozdemir 1 , Neslihan Cuhaci 1 , Husniye Baser 1 , Ahmet Dirikoc 1 , Cevdet Aydin 1 , Aylin Kilicyazgan 2 , Reyhan Ersoy 1 & Bekir Cakir 1
1Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey; 2Ataturk Training and Research Hospital, Department of Pathology, Ankara, Turkey.
Introduction: In this study, we aimed to evaluate the usefulness of ratio of primary tumor diameter to total tumor diameter as a new parameter for the differentiation of agressive and favorable papillary thyroid microcarcinomas (PTMC).
Methods: The diameter of the largest tumor focus was taken as the primary tumour diameter (PTD). For multifocal tumors, total tumor diameter (TTD) was calculated as the sum of the maximal diameter of each lesion. A ratio was obtained by dividing PTD to TTD and defined as tumor diameter ratio (TDR) (PTD/TTD=TDR). Positive (PPV) and negative predictive values (NPV) and sensitivity and specifity of TDR to predict capsular invasion, extrathyroidal extension (ETE) and lymph node metastasis (LNM) were determined.
Results: Mean TDR significantly decreased as number of tumor foci increased. In multifocal PTMCs, the sensitivities of TDR for the detection of LNM, ETE and capsular invasion were 100%, 100% and 94.2%, respectively, the specifities were 86.2%, 88% and 94.7%, respectively. TDR had a PPV of 99.3% and NPV of 100% for LNM; PPV of 58.5% and NPV of 100% for ETE; and PPV of 89.1% and NPV of 97.3% for capsular invasion. In patients with multifocal PTC>10 mm, mean TDR was signficantly lower in patients with LNM compared to ones without LNM (0.76±0.12 vs 0.44±0.10; P<0.001).
Conclusion: Decreased TDR was associated with capsular invasion, ETE and LNM in patients with multifocal PTMC. It was also predictive for LNM even in patients without capsular invasion or ETE. This new parameter might be particularly helpful for the detection of aggressive behavior in multifocal PTMCs.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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