ECE2016 Eposter Presentations Thyroid cancer (81 abstracts)
Ultrasonographic scoring index can be useful in the prediction of thyroid malignancy in subcentimeter and supracentimeter thyroid nodules
Neslihan Cuhaci 1 , Berna Ogmen 2 , Ali Tam 1 , Cevdet Aydin 1 , Oya Topaloglu 1 , Aylin Kilic Yazgan 3 , Gurkan Dumlu 4 , Reyhan Ersoy 1 & Bekir Cakir 1
1Ankara Yildirim Beyazit University School of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey; 2Atatürk Education and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey; 3Atatürk Education and Research Hospital, Department of Pathology, Ankara, Turkey; 4Ankara Yildirim Beyazit University School of Medicine, Department of General Surgery, Ankara, Turkey.
Introduction: The increased rate of thyroid malignancy as well as incidental and subcentimeter thyroid nodules have been attributed to increasing use of high-resolution US which can detect the non-palpabl or subcentimeter (maximum diameter ≤1 cm) thyroid nodules. We aimed to evaluate the sonographic features of the tyroid nodules between ≤1 cm and > 1 cm according the histopathology results and to determine the ultrasonographical predictive factors for malignancy and an ultrasonographic score according the sonographic features to avoid unnecessary fine-needle aspiration biopsy (FNAB).
Methods: We retrospectively evaluated 2233 nodules of 1118 patients who underwent thyroidectomy. Predictive factors for distinguishing between malignant and benign histopathologic results according the ultrasonographic features were evaluated by multivariate logistic regression analysis. Multiple binary logistic regression with the forward logistic regression method was used to develop the formula for recommending sonographically guided biopsy.
Results: Among the 2233 nodules 337 nodules were in the ≤1 cm (group 1), 1896 were in the >1 cm (group 2). According the histopathological results, in group 1; 173 nodules were in the benign, 164 nodule were in the malignant group. Whereas in group 2; 1423 nodules were in the benign, 473 nodules were in the malignant group. In group 1, AP/T ≥1, the presence of microcalcification, macrocalcification and hypoechoic pattern were significantly higher in the malignant group and in group 2, the presence of microcalcification, macrocalcification, hypoechoic and iso-hypoechoic pattern, solid texture, peripheral and intranodular vascularization pattern were significantly higher in the malignant group. In group 1, the best ultrasonographic index score was found >2, whereas in group 2 the it was found >4.
Conclusion: Our US scoring may lead to clinicians and surgeons to diagnose thyroid malignancy more accurately and to select the nodules for FNAB especially in subcentimeter nodules.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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