ECE2016 Eposter Presentations Thyroid cancer (81 abstracts)
The diagnostic value of FNAB for early diagnosis of thyroid cancer: a Greek center experience
Eleni Triantafillou 1 , Georgios Papadakis 1 , Paraskevi Manitarou 1 , Evgenia Panagiotidi 1 , Fotini Kanouta 1 , Aspasia Drosou 1 , Philippos Kaldrymidis 1 , Victoria Kaltzidou 1 , Eleni Tsouma 2 , Anastasia Alexiadou 2 , Styliani Plyta 2 & Athanasia Tertipi 1
1Department of Endocrinology, Metaxa Anticancer Hospital, Pireaus, Athens, Greece; 2Department of Cytology, Metaxa Anticancer Hospital, Pireaus, Athens, Greece.
Introduction: Fine needle aspiration biopsy (FNAB) is the initial investigation of choice for thyroid nodules.
Methods: A total of 563 patients (106 males/457 females) underwent FNAB for the same number of thyroid nodules. Their mean age was 56.1±14.1 years. We correlated the demographic profile (age and gender) and sonographic features of these nodules with the FNAB outcome. The Bethesda system for reporting thyroid cytopathology was used.
Results: Out of total 563 cases, 190 (33.7%) cases were diagnosed as non diagnostic (B1), 339 (60.2%) were diagnosed as benign (B2), 17 (3.0%) as B3 (atypia/follicular lesion of undetermined significance), 7 (1.2%) as B4 (follicular neoplasm or suspicious for follicular neoplasm), while 5 (0.9%) cases were categorized as B5 (suspicious for malignancy) and 5 (0.9%) as B6 (malignant). Remarkably, two nodules of category B5 and B6 each had a maximum diameter of 9 mm and 8 mm respectively. When comparing benign result (B2) vs result of category B3–6, irregular shape (7.1% in B2 vs 17.6% in B3–6, X2=4.66, P=0.043), ill-defined margins of the nodule (13.3% in B2 nodules vs 29.4% in B3-6 nodules, X2=6.4, P=0.020), and the presence of calcifications (34.2% in B2 nodules vs 64.7% in B3-6 nodules, X2=12.3, P=0.001) decreased significantly the possibility for benign (B2) result, whereas features such as the size of nodule, the presence of central vascularity, the composition and the hypoechogenity of the nodule did not affect the possibility for B2 vs B3–6 result. Finally, there was no association of gender and age with the Bethesda category result.
Conclusion: Our study supports that the irregular shape of a nodule, ill defined margins, and the presence of calcifications decrease the possibility of a Bethesda benign result. FNAB of nodules <10 mm may reveal suspicious or positive for malignancy cytology.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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