ECE2016 Eposter Presentations Thyroid cancer (81 abstracts)
Comparisson between two differnet protocols for the management of patients with differnetiated thyroid cancer
Nicolás Crisosto , Vjeroka Inostroza , Cristián Campos , Francisca Gajardo , Pamela Invernizzi , Felix Vasquez , Paola Hernández , Cecilia Pereira , Amanda Ladrón de Guevara , Miguel Dominguez & Erika Diaz
Unit of Endocrinology, Hospital San Juan de Dios, Santiago, Chile.
Introduction: New techniques such as etapification ecotomography (EE) have led to less invasive surgeries in Differentiated Thyroid Cancer (DTC). The trend in recent years has been to a reduction in the doses of radioiodine administered. Our hospital in 2013 incorporated these features to protocolize the administration of radioiodine depending on the characteristics of the tumour and the initial thyroglobulin levels, which may have had an impact in the response to treatment (RT) compared to our previous practice.
Methods: Analysis of clinical records from patients that underwent Total Thyroidectomy for DTC. Protocol 2012: no EE and RI dose between 50-200 mCi. Protocol 2013, with EE and RI dose between 0-150 mCi. Patients were classified according to the ATA risk for recurrence scale. RT was evaluated after one year as excellent, acceptable or incomplete.
Results: 84 patients from the 2012 protocol and 93 patients from the 2013 protocol were analyzed. Age, sex and histology were comparable between both groups. The 2013 group underwent more conservative surgeries with a lower percentage of patients undergoing lateral dissections. The ATA risk distribution was comparable between the two groups (P=0.978) Radioiodine dosages administered to the 2013 group were significantly lower according to their risk group. The RT distribution at one year follow up was similar between both groups. The percentage of patients with an excellent response was comparable in the Low Risk (2012: 80 vs 2013: 88% ; P=0.22) Intermediate Risk (2012: 62.5 vs 2013: 70.2% P=0.446) and High Risk (2012: 38 vs 2013: 50% P=0.546) ATA categories.
Conclusions: We observed that the 2013 protocol has a RT comparable to the 2012 protocol. This allowed us to perform less invasive surgeries due to the incorporation of EE and it supports the use of lower doses of RI.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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