Endocrine Abstracts

Purpose: Papillary and follicular cancers are classified as differentiated thyroid cancers. Recently, it has been revealed that Neutrophile/lymphocyte ratio (NLO) and the ratio of monocyte/lipoprotein cholesterol with high density (MHR) are the strong indicators of oxidative stress and systemic inflammation. In this study, we intend the evaluation of all these indicators in our patients diagnosed with differentiated thyroid cancers.

Method: This study included 182 persons which 107 of them were diagnosed with differentiated thyroid cancer in our clinic and 75 of them who were healthy and no significantly different in regard to age and body mass index (BMI) statically were in the control group. The mean age of patients was 45.9±14.7 years and the mean age of control group was 48.2±7.7 years. There was no a significant difference statistically between them (P=0.1). The BMI mean of the patients was calculated as 28.0±4.7 kg/kg/m² and the BMI mean of the control group was calculated 27.2±3.3 kg/kg/m². It was not detected a significant difference between them statistically (P=0.5). Cholesterol and hematologic parameters of the patients and the control group after 12 hours fasting were evaluated after studied.

Result: It was detected a significant difference statically between the patients and the control group respectively in NLO mean (3.2±2.8 and 2.4±1.3 P=0.013), MHR ratio (0.038±0.05 and 0.1±0.07 P=0.000) as the result of the study. In the correlation analysis, there was a positive correlation respectively MHR and Neutrophile(r=0.4 P=0.000), lymphocyte (r=0.4 P=0.000) and thyroglobuline (r=0.4 P=0.000), and it was determined a negative correlation between NLO and respectively lymphocyte (r=−0.2 P=0.000), monocyte (r=−0.18 P=0.01).

Discussion: It was observed that differentiated thyroid cancers increase systemic inflammation based on the data provided by this study.