ECE2016 Eposter Presentations Thyroid cancer (81 abstracts)
Usefulness of Day 5 sampling in thyroid cancer patients for radioactive iodine therapy with recombinant human thyrotropin
Seo Young Sohn 1 , Eun Kyung Lee 2 , You Jin Lee 2 , Yul Hwangbo 2 , Hae Jin Jun 2 , Dae Yoon Park 2 , Ji Hyun Kim 2 & Junsun Ryu 2
1Seonam University, Myongji Hospital, Goyang, Republic of Korea; 2National Cancer Center, Goyang, Republic of Korea.
Background: We evaluated the impact of several anthropometric parameters on serum peak TSH levels after standard two-dose of recombinant human thyrotropin (rhTSH) injection and assessed the usefulness of repeated measurement of TSH and thyroglobulin (Tg) levels at 24 and 72 h after rhTSH injection (Day 3 and 5) to confirm stimulated Tg level.
Methods: We retrospectively reviewed 270 differentiated thyroid carcinoma patients who underwent rhTSH stimulation for radioactive iodine therapy in our clinic between 2013 and 2014. Serum TSH and Tg level were measured twice Day 3 and 5 after rhTSH injection. Univariate and multivariate analyses were performed to elucidate predictive factors of the peak TSH level. The repetitive values of TSH, Tg and TgAb were compared by two-tailed paired T-test.
Results: By univariate analysis, peak TSH level (Day 3 TSH) was positively correlated with age and serum creatinine, and negatively correlated with weight, height, body surface area (BSA) and glomerular filtration rate (GFR) (P<0.01). GFR and BSA were independently associated with peak TSH level by multivariate analysis (standardized β coefficient =−0.36; P<0.001 and −0.23; P<0.01, respectively). On the subgroup analysis of sixty patients with repetitive measurements, rhTSH-stimulated Tg level on Day 5 was significantly higher than that of Day 3 (0.71 ng/ml vs. 0.54 ng/ml, P=0.006).
Conclusions: Body size and renal function influence serum peak TSH levels after rhTSH injection. On this basis, more personalized rhTSH dosage could be used in clinical practice, adjusted for BSA and GFR. The repeated measurement on Day 5 seemed to be necessary to assess stimulated Tg level.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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