How does energy intake influence the levels of certain steroids?

Hana Jandikova; Michaela Duskova; Beata Racz; Hana Pospisilova; Monika Sramkova; Martin Hill; Karel Vondra; Luboslav Starka

doi:10.1530/endoabs.41.EP963

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Endocrine Abstracts (2016) 41 EP963 | DOI: 10.1530/endoabs.41.EP963

ECE2016 Eposter Presentations Steroid metabolism + action (13 abstracts)

How does energy intake influence the levels of certain steroids?

Hana Jandikova , Michaela Duskova , Beata Racz , Hana Pospisilova , Monika Sramkova , Martin Hill , Karel Vondra & Luboslav Starka

Err

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Institute of Endocrinology, Prague, Czech Republic.

Introduction: The influence of steroid hormones on food intake is well described. However, there are only a few studies on the effect of food intake on steroid levels.

Methods: The study involved eight non-smoker women (average age 29.48±2.99 years; average BMI 21.3±1.3 kg/m²); they did not use any kind of medication affecting steroidogenesis. We analysed the influence of four various stimuli on the levels of steroid hormones and melatonin. During their follicular phase of menstrual cycle, each woman had an oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IVGTT), a standard breakfast and psyllium (a non-caloric fibre). The samplings were performed fasting in the morning, at 20, 40, 60, 90, and 120 minutes.

Results: Cortisol declined during each test, which is a physiological decline in the morning hours. In all tests (except of the application of the non-caloric fibre, psyllium), however, this decline was modified. After the standard breakfast there was an increase in cortisol at 40th minute. The OGTT and IVGTT tests led to a plateau in cortisol levels. Testosterone levels showed no relationships to tested stimulations. After the initial decline there was an increase in DHEA after all stimuli.

Conclusion: Despite the fact that we performed the tests in the morning hours, when steroid hormone levels physiologically start to change due to their diurnal rhythm, we still found that food intake influences some of the hormone levels.