ECE2016 Eposter Presentations Steroid metabolism + action (13 abstracts)
Sex hormones and sleep in men and women from the general population: a cross-sectional observational study
Hanna Kische 1 , Ralf Ewert 2 , Ingo Fietze 3 , Stefan Gross 4, , Henri Wallaschofski 1, , Henry Völzke 4, , Marcus Dörr 4, , Matthias Nauck 1, , Anne Obst 2, , Beate Stubbe 2 , Thomas Penzel 3 & Robin Haring 1,
1Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany; 2Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; 3Interdisciplinary Sleep Center, Charité, University Medicine Berlin, Berlin, Germany; 4DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany; 5Department of Cardiology, University Medicine Greifswald, Greifswald, Germany; 6Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; 7Faculty of Applied Public Health, European University of Applied Sciences, Rostock, Germany.
Introduction: To date, associations between sex hormones and sleep were mainly investigated in small and selected patient-based samples. Thus, we examined a comprehensive panel of mass spectrometry-measured sex hormones and various sleep characteristics in a population-based sample of healthy men and women from the general population.
Methods: We used data from 204 men and 213 women of the cross-sectional Study of Health in Pomerania TREND, who underwent cardiorespiratory polysomnography. Associations of total and free testosterone (TT, fT), androstenedione (ASD), estrone (E1), estradiol (E2), DHEAS, sex hormone-binding globulin (SHBG), and E2/TT ratio with sleep measures (including total sleep time, sleep efficiency, wake after sleep onset (WASO), apnea-hypopnea index (AHI), insomnia severity index, epworth sleepiness scale (ESS), and Pittsburgh sleep quality index) were assessed by sex-specific multivariable regression models adjusting for age, waist circumference, hypertension, smoking, physical inactivity, and alcohol consumption. Sensitivity analyses were performed with stratification by diagnosis of depression and menopausal status (women).
Results: In men, associations of TT (β-coefficient per S.D.: 0.62; 95% CI: 0.46–0.83), fT, SHBG, and E2/TT ratio with AHI in age-adjusted analyses were rendered non-significant after multivariable adjustment. In multivariable analyses, ASD (β-coefficient: 1.37; 95% CI: 1.03–1.82) and SHBG were associated with ESS. In women, only age-adjusted models showed an inverse association of SHBG with AHI (β-coefficient: 0.55; 95% CI: 0.38–0.78). Multivariable analyses showed positive associations of DHEAS with WASO (β-coefficient: 0.16; 95% CI: 0.03–0.28) and of E2 (β-coefficient: 1.04; 95% CI: 0.37–1.72) and E2/TT ratio with ESS.
Conclusion: Consistent with previous findings, the present cross-sectional population-based study observed sex-specific associations of testosterone and estrogen with sleep disturbances and poor sleep quality. However, multivariable-adjusted analyses confirmed the relative impact of body composition, health-related lifestyle, and comorbidity on the association between sex hormones and sleep.
Volume 41
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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