Endocrine Abstracts

Background: Post traumatic Hypopituitarism (PTHP) is common, its prevalence is about 30%.

Aim: The aim is firstly to assess the frequency and predictive factors of hypopituitarism 3 and 12 months following Brain injury (BI) in a simple of 133 victims of moderate to severe BI in two neighbors’ hospitals in the east of Algiers. Secondly is to evaluate the quality of life and neurocognitive status of this cohort.

Method: Hypopituitarism, evaluation of quality of life and neurocognitive status were searched in 133 victims of moderate to severe BI.

Result: Mean age was 32 years with male predominance. Traffic accident was the most frequent cause of BI. The frequency of PTHP at three months after injury was 44% with 31.5% of corticotrop failure, 18% of GH deficiency, 6.8% of gonadotropin deficiency, 6.8% of hypoprolactinemia, 1.5% of thyrotrophic deficiency and 3.8% of hyperprolactinemia. Predictive factors of occurrence of PTHP was skull base fracture, duration of intubation and coma and initial traumatic imaging. The prevalence of PTHP at twelve months after injury was 34.5% with 25% of corticotropic failure, 17.2% of GH deficiency, 8.6% of gonadotropic deficiency, 5.17% of hypoprolactinemia, 0.9% of thyrotrophic deficiency and 8.6% of hyperprolactinemia. Predictive factors of Twelve months PTHP was the duration of intubation and coma and polytraumatism. Among the patients with PTHP at three months 50.8% still in hypopituitarism. 14.8% of non PTHP patients at three months developed PTHP at 12 months. 40.67% of patients with hypopituitarism at three months have recovered their pituitary functions at 12 months. A link was found between PTHP and impairment of quality of life at 3 months and one year using AGHDA and SF-36 scales. PTHP patients have more neurocognitive disorders using NRS-R scale than non hypopituitaric patients at three months but not at 12 months after the injury.