ECE2016 Eposter Presentations Pituitary - Clinical (83 abstracts)
Acromegalic cardiomyopathy: echocardiographic and CMR analysis
Alvise Casara 1 , Francesca Dassie 1 , Marialberta Battocchio 1 , Matteo Parolin 1 , Chiara Martini 1 , Eugenio De Carlo 1 , Roberto Mioni 1 , Giulia Famoso 2 , Francesco Tona 2 , Francesco Fallo 1 , Roberto Vettor 1 , Francesco Corbetti 3 & Pietro Maffei 1
1Department of Medicine, University of Padua, Padua, Italy; 2Department of Cardiac, Thoracic and Vascular Sciences, University of PAdua, Padua, Italy; 3Cardiac magnetic resonance unit, Albignasego, Italy.
Introduction: Acromegalic cardiomyopathy is characterized by myocardial hypertrophy and interstitial myocardial fibrosis at biopsy. We studied left ventricular hypertrophy -LVH- through echocardiography (-ECHO- 2-D standard echocardiography and Doppler analysis) and cardiac magnetic resonance (CMR) analysis. Myocardial fibrosis was studied with late enhancement technique (LE) and extracellular volume technique (ECV) at CMR.
Methods: 25 patients -pts- (13 males) with an average age of 49.24±11.96 yy, mean IGF-1 324(186-626) ug/L, 17pts with active disease, 9 pts had a newly diagnosed disease. Results of the CMR (on 24 pts) were compared with those of 20 controls -CTR- matched for sex and age.
Results: On ECHO: 10pts reported LVH (mean left ventricular mass index LVMi=118.83±26.32 g/m2), 17 pts had first grade diastolic dysfunction (E/A=0.81±0.3). There was no correlation between the echocardiography data and IGF-1. On CMR: 5pts had LVH (median LVMi=64.2g/m2). Pts with LVH had higher IGF-1 levels than pts without LVH (Median=801 μg/l vs 267 μg/l; P=0.01); pts with active disease had higher LVMi values than non-active pts (Median=70.2 g/m2 vs 61g/m2; P=0.007); there was a significant correlation between IGF-1 and LVMi (r=0.63; P<0.05). LE was found in 9 pts. Pts’s ECV was significantly elevated in comparison to CTR (pts=24.05±3.2% vs CTR=19.99±1.58% P<0.0001). LVMi at CMR had a significant correlation with LVMi at echocardiography (r=0.5, P<0.05).
Conclusions: This study confirms that LVH and diastolic dysfunction are key features of acromegalic cardiomyopathy. Both macroscopic (LE) and interstitial fibrosis (ECV) are common findings in acromegaly.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more