Endocrine Abstracts

Introduction: T1DM is caused by immune mediated destruction of pancreatic β-cells, leading to partial, or absolute insulin deficiency.The most frequent age of onset is 12 years. IGF-1 is a polypeptide with 70 amino acids and its chemical structure is similar to insulin. IGF-1 is associated with early development and has anabolic effect in adults. IGF-1 regulates many physiological functions, including glucose metabolism, cell survival and proliferation.

Objectives: To compare IGF-1 levels in type-1 diabetic children with that of healthy controls and to find relationship between IGF-1 and physical features in T1DM

Patients and Methods: This study involved 85 children less than 12 years old.Seventy Patients with T1DM selected according to ADA 2014 criteria for diagnosis of diabetes from pediatric diabetes clinic at Ain Shams University hospital divided into 2 groups based on duration of diabetes to T1DM>1 year duration and T1DM<1 year duration. fifteen normal children attending the pediatric general clinics as a control group. height, weight, arm span, upper body segment, lower body segment, body mass index, parents height beside Fasting blood glucose, HbA1C, IGF-1, FSH, LH were assessed.

Results: Height percentile significantly higher in T1DM > 1year group median 50 (10 to 75) than T1DM < 1 year (median 10 (3 to 44) P-value 0.007). IGF-1 level in group T1DM > 1 year median 90 (70 to 110) (ng/ml) was significantly lower than other groups (P-value 0.0008). IGF1 has a significant positive relation with Aram span in group T1DM< 1year (P-value 0.024), positive significant relationship between mother height and IGF-1 level in group T1DM> 1 year (P-value 0.013).

Conclusion: IGF-1 level is reduced in recent onset T1DM but still can have some effect on somatic features even in the pressence of longstanding diabetes.