Endocrine Abstracts

The aim: To examine menstrual disorders in women with obesity in fertile age.

Material and methods: We observed the reproductive health of 25 women with obesity and infertility (1 st group). Second group of patients consisted from 25 healthy women without obesity. The age of patients of 1 st group was from 20 to 39 years old, in average 28.3±0.64. The age of patients of 1 st group was from 22 to 37 years old, in average 30.4±0.51/

To all patients have been conducted spectrum of investigations, which include clinical, biochemistry – whole blood and urine analysis, lipid spectrum, radioimmune hormonal analysis of the blood (prolactin, LH, FSH, insulin, estradiolum, testosterone, progesterone, free thyroxin, dehydroepyandrostendione, 17 oxyprogesterone), antimuller hormone). Besides of this, electrocardiography, ultrasound investigation of uteri and ovarium during 11–14 days of periods, and MRY of pituitary.

The results of the study: The investigation of hormonal profile of 1 st group showed that hormonal profile of 1 st group showed that average level of hormones in 14 day of periods was follow: LH- 21.1±2.1 mME/l (average norm - 28.7 mME/l), FSH -4.7±0.5 mME/l (average norma 22.1 mME/l), prolactin – 5.1±0.5 mmol/l (average norm is 5.7 mmol/l), free testosterone – 4.6 ng/ml (average norm < 1.0 ng/ml). Then, in 1 group of patients were found more low data of average levels of LH, FSH, free testosterone. The level of ACTH, TSH, free thyroxine and cortisol were normal.

Conclusions: We established, that in fertile age women with obesity in the basis if menstrual dysfunction take place hyperandrogenic anovulation on the condition of hyperinsulinemiya.