Endocrine Abstracts

Metabolic Syndrome (Met S), is associated with increased risk of cardiovascular disease (CVD) and mortality, the presence of 1 or 2 components of the (MetS) increases overall mortality compared with the absence of any component of the (MetS). Epidemiological studies have shown that low testosterone is associated with MetS. While testosterone levels decline with age, Estradiol (E2) levels remain relatively stable resulting in a decreased testosterone: E2 ratio (T:E), Whether theses hormonal pattern changes play a role in the development of Met S should be further assessed.

Objective: To study the relation between endogenous sex hormones with different components of MetS.

Design: The study was conducted on 80 egyptian males divided into Gr 1: 40 males with Met S and Gr 2:40 healthy males of matched age.

Results: Gr 1 had significant higher body mass index(BMI)(Gr 1:32.3±3.8, Gr2:28.4±4), Waist circumference (WC) (Gr1:110.5±7, Gr2:100.7±6.4) systolic blood pressure (SBP) (Gr1:135.5±12.1, Gr2:117.3±3.6), diastolic blood pressure (DBP) (Gr1:94.3±10.6, Gr2:74.9±3.4) cholesterol (Gr1: 275.4±32.2, Gr2:155.7±29.9) LDL (Gr1:175.4±34.9, Gr2:77.8±31.1) TG(Gr1:301.6±29.9, Gr2:138.3±24.5) Fasting blood sugar (Gr1:111.1±6.9,Gr2:90.8±9.5) Fasting insulin (Gr1:6.9±1.6, Gr2:4.1±1.7) HOMA-IR (Gr1:1.89±0.48, Gr2:0.93±0.39) E2 (Gr1:20.3±4.3, Gr2:14.6±5.6) and significantly lower HDL (Gr1:39.6±7, Gr2:50.2±4.8).Gr 1 had significant lower testosterone (2.1±0.64) than Gr2(3.27±0.58) lower T:E ratio (Gr1: 0.11±0.05, Gr2: 0.25±0.09), and significant higher E2 (Gr1: 20.3±4.3, Gr2: 14.6±5.6) testosterone was significantly inversely correlated with weight, BMI, WC cholesterol, LDL, TG, FBS, Fasting insulin and HOMA-IR and positively correlated with HDL.E2 was significantly positively correlated with cholesterol, LDL, FBS, fasting insulin and HOMA-IR, Cutoff value for E2 (>16.78) with sensitivity 92.5% and specificity 82.5% and cutoff value for testosterone (<2.37) with sensitivity 67.5% and specificity 95%.

Conclusion: Patients with MetS had significant lower testosterone and T:E2 ratio and significant higher E2.Testosterone and E2 are significantly associated with various components of the MetS.