ECE2016 Eposter Presentations Obesity (69 abstracts)
The level of SCD1 in subcutaneous adipose tissue is associated with the presence of metabolic syndrome in morbidly obese patients
Sara Garcia-Serrano 1, , Carolina Gutierrez-Repiso 1 , Francisca Rodriguez-Pacheco 1 , Ailec Ho-Plagaro 1 , Eva Garcia-Escobar 1, , Miguel A Alaminos-Castillo 1 , Lourdes Garrido-Sanchez 3, , Sergio Valdes 1, , Montserrat Gonzalo 1 , Alberto Rodriguez-Cañete 5 , Custodia Montiel-Casado 5 , Javier Moreno-Ruiz 5 & Eduardo Garcia-Fuentes 1,
1Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Regional University Hospital, Malaga, Spain; 2CIBER of Diabetes and Associated Metabolic Disorders (CIBERDEM), Instituto de Salud Carlos III, Malaga, Spain; 3Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, Malaga, Spain; 4CIBER Physiopathology of Obesity and Nutrition (CIBERObn), Instituto Salud Carlos III, Malaga, Spain; 5Department of Surgery, Biomedical Research Institute of Malaga (IBIMA), Regional University Hospital, Malaga, Spain.
Introduction: The stearoyl-CoA desaturase 1 (SCD1) is an enzyme involved in the metabolism of fatty acids, and seems to be involved in the regulation of atherosclerosis development. In this study we want to check the expression of SCD1 in visceral and subcutaneous adipose tissue and its relationship with the metabolic syndrome.
Methods: We measured SCD1 mRNA and protein expression in visceral and subcutaneous adipose tissue from 25 morbidly obese patients. Patients were classified into two groups based on whether or not to have metabolic syndrome (according to the IDF 2005 criteria).
Results: SCD1 mRNA expression in subcutaneous adipose tissue is significantly lower in those subjects with metabolic syndrome (P=0.036), while SCD1 protein is significantly higher (P=0.005). The subjects who meet the HDL or glucose criteria are those with lower SCD1 mRNA expression and higher SCD1 protein levels. In visceral adipose tissue, no association was found between SCD1 mRNA or protein levels and metabolic syndrome.
Conclusions: The presence of metabolic syndrome in morbidly obese patients seems to be associated with SCD1 levels in subcutaneous adipose tissue.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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