Endocrine Abstracts

Introduction: The prevalence of obesity has increased, reaching epidemic proportions. Framingham and REGICOR scales predict the likelihood of developing a coronary event in the next 10 years. The aim of this study was to assess the concordance of these scales in the stratification of cardiovascular risk (CVR) in a cohort of patients with morbid obesity.

Methods: We designed a cross-sectional study in a sample of patients with morbid obesity evaluated from 2005 to 2012. The estimation of CVR at 10 years was determined according to the Framingham-Wilson Score and its adaptation to Mediterranean populations (REGICOR scale). These scales include the following variables: age, sex, total cholesterol levels, HDL cholesterol, systolic blood pressure, presence of diabetes (T2DM) and smoking. Depending on the results, they were classified into 3 categories: low risk (<10%), intermediate (10–20%) and high (>20%).

Results: A total of 211 patients were included. The mean age was 37.9±9.8 years and 157 were female (74%). The mean BMI was 51.13±7.11 kg/m². Regarding cardiovascular risk factors, 75 (35.7%) patients had hypertension, 75 (35.7%) dyslipidemia, 62 (29.5%) smoking and 53 (25.2%) T2DM. Total cholesterol mean levels were 197.27±38.85 mg/dl and HDL 44.19±11.53 mg/dl. The results for the estimation of CVR with the REGICOR scale were: 93.9% of patients with low risk, 5% intermediate and 1% high risk, while those with the Framingham score were: 77.2% low risk, 13.9% intermediate and 8.9% high. The mean CVR estimation was 3.08±2.85 with REGICOR versus 6.16±7.02% with Framingham (P<0.001). The Kappa index of agreement between the scales was 0.231.

Conclusion: In our series, the CVR estimated by Frammigham score was superior to that obtained by REGICOR scale. A positive correlation between both scales was obtained but with a fair agreement. These results support the importance of CVR scales adjusted for each population.