Endocrine Abstracts

Introduction: Few studies have investigated the effect of gastric bypass surgery on lipid profile in obese patients with type 2 diabetes mellitus. We aimed to evaluate changes in lipid profile in obese diabetic patients undergoing Roux-en-Y gastric bypass (RYGB) surgery.

Method: We retrospectively analysed 71 obese type 2 diabetic patients (46 women, 25 men) who underwent RYGB surgery. Weight, body mass index (BMI), total cholesterol (TC), high-density-lipoprotein cholesterol (HDLc), low-density-lipoprotein cholesterol (LDLc) and triglyceride (TG) levels were evaluated before and 3 months after the surgery.

The study was conducted at the Inonu University, Turgut Ozal Medical Center. The same surgery team performed all operative procedures laparoscopically. Institutional ethics committee approved the study protocol.

Results: Mean age of the patients was 44.96±9.66 years. Pre-operative mean BMI and weight were 45.72±8.66 kg/m² and 138.78±26.15 kg respectively. 3 months after the surgery both mean BMI and weight significantly decreased to 33.68±6.15 kg/m² (P<0.001) and 101.55±24.96 kg (P=<0.001) respectively.

3 months after the RYGB, there was a significant decrease in TC (213.62±45.33 to 173.50±35.29 mg/dl, P<0.001) and TG (272.53±320.96 to 134.93±58.52 mg/dl, P<0.001) and HDLc (40.18±9,59 to 37.19±10.17 mg/dl, P<0.005) levels. However, decrease in LDLc (123.31±42.32 to 109.52±30.83 mg/dl, P=0.126) level was not statistically significant.

Changes (Δ) from preoperative TC (−40.27±48.74 vs. – 26.50±54.70 mg/dl, P<0.001), LDLc (12.30±48.02 vs. −11.02±42.33 mg/dl, P=0.058) and HDLc (−1.67±11.47 vs. −3.9±9.31 mg/dl, P<0.006) levels were more prominent in patients with BMI ≥40 kg/m² compared to the BMI< 40 kg/m² respectively.

Conclusions: Our results indicate that RYGB may have beneficial effects on TC, LDLc and TG but not on HDLc levels in obese patients with type 2 DM. Longer follow up period is required to validate our results.