ECE2016 Eposter Presentations Obesity (69 abstracts)
Hif-1α is positively associated with scavenger receptors Lox-1, Cxcl16 and Msr1 in adipose tissue
Concepción Santiago-Fernandez 1 , Jose M. Garcia-Almeida 1, , Luis Ocaña-Wilhelmi 3 , Alejandro Rodriguez-Morata 4 , Carolina Gutierrez-Repiso 5 , Monica Tomé 1 , Juan Alcaide 1 , Francisco J Tinahones 1, , Franz Tatzber 6 , Edith Pursch 7 , Eduardo García-Fuentes 2, & Lourdes Garrido-Sánchez 1,
1Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, Malaga, Spain; 2CIBER Physiopathology of Obesity and Nutrition (CIBERObn), Instituto Salud Carlos III, Malaga, Spain; 3Department of Surgery, Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, Malaga, Spain; 4Department of Angiology and Vascular Surgery, Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, Malaga, Spain; 5Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Regional University Hospital, Malaga, Spain; 6Medical University of Graz, Centre of Molecular Medicine, Institute of Pathophysiology & Immunology, Graz, Austria; 7University of Applied Sciences Technikum Wien, Institute of Biochemistry, Vienna, Austria.
Introduction: HIF-1α, a hypoxia marker, is an important factor for transcriptional regulation of cell metabolism and the adaptation to cellular stress. It modulates the function of phagocytic cells by stimulating surface receptors such as scavenger receptors. But little is known on their relationship in adipose tissue, whose increase has been associated with an increased risk of atherosclerosis. The aim of this study is to analyze in adipose tissue the association between mRNA expression levels of HIF-1α and different scavenger receptors, and their relationship with the presence of obesity.
Design: We study in 21 normal weight and 26 morbidly obese patients (MO) the mRNA gene expression levels of HIF-1α and different scavenger receptors (lectin-like oxLDL-1 (LOX-1), macrophage scavenger receptor 1 (MSR1) and chemokine (C-X-C motif) ligand 16 (CXCL16)) in visceral (VAT) and subcutaneous adipose tissue (SAT).
Results: HIF-1α and LOX-1 mRNA gene expressions are increased in VAT from MO patients (P=0.025 vs. P=0.003, respectively), but not in SAT. MSR-1 and CXCL16 mRNA gene expression levels are higher in MO patients in VAT and SAT (VAT: P=0.001 vs. P<0.001, respectively, and SAT: P<0.001 vs. P<0.001, respectively). HIF-1α mRNA gene expression in VAT has positively correlated with the weight, body mass index and waist circumference, and negatively with serum HDL and adiponectin levels. HIF-1α mRNA gene expression is positively associated with MSR1 and CXCL16 in VAT and SAT, and positively with LOX-1 mRNA expression only in VAT.
Conclusions: In this study we demonstrate the positive association in the adipose tissue between the mRNA gene expression level of HIF-1α, a hypoxia marker, and different scavenger receptors.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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