ECE2016 Eposter Presentations Obesity (69 abstracts)
Visceral adiposity index as a marker of hepatic steatosis in overweight and obese premenopausal women
Evangeline Vassilatou 1 , Dimitra Vassiliadi 1 , Helen Lazaridou 2 , Nikitas Koutsomitopoulos 1 , Nikolaos Kelekis 2 , Dimitrios Hadjidakis 1 & George Dimitriadis 3
1Endocrine Unit, 2nd Department of Internal Medicine – Propaedeutic, “Attikon” University Hospital, Haidari, Athens, Greece; 22nd Department of Radiology, “Attikon” University Hospital, Haidari, Athens, Greece;
32nd Department of Internal Medicine – Propaedeutic,“Attikon” University Hospital, Haidari, Athens, Greece.
Introduction: Visceral adiposity index (VAI), initially developed as an indicator of visceral adipose function for the assessment of cardiometabolic risk, has been also proposed for the detection of nonalcoholic fatty liver disease (NAFLD). However, the diagnostic performance of VAI as a marker of hepatic steatosis (HS) is still under investigation.
Objective: To evaluate the accuracy of VAI as a marker of HS in a cohort of overweight and obese premenopausal women and to compare diagnostic performance of VAI and of two other HS markers: fatty liver index (FLI) and lipid accumulation product (LAP) index.
Design: Prospective, cross-sectional study.
Patients – methods: Anthropometric measurements, biochemical testing and abdominal ultrasonography after excluding causes of secondary liver disease were performed in 110 overweight and obese premenopausal women, aged 18–45 years, including 40 women with polycystic ovary syndrome (PCOS). The three markers of HS - VAI, FLI and LAP - were calculated. The diagnostic performance of VAI, FLI and LAP was assessed with receiver operating characteristic (ROC) analysis.
Results: NAFLD was detected in 71/110 (64.5%) women (31 PCOS and 40 non PCOS) by ultrasonography. VAI, FLI and LAP values were higher in HS(+) compared to HS(−) women [2.3±1.8 vs. 1.3±0.7 (P<0.01), 68.4±28.1 vs. 33.3±22.7 (P<0.001) and 60.8±41.7 vs. 28.6±13.9 (P<0.001) respectively]. The area under the curve (AUROC) for VAI, FLI and LAP was 0.71, 0.82 and 0.79, respectively.
Conclusions: These data indicate that calculation of VAI is useful for detecting NAFLD in overweight and obese premenopausal women. However, FLI and LAP seem to have a superior diagnostic performance.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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