ECE2016 Eposter Presentations Obesity (69 abstracts)
Effects of bariatric surgery on blood pressure of non-hypertensive obese patients
João Sérgio Neves 1 , Sofia Castro Oliveira 1, , Pedro Souteiro 1, , Rita Bettencourt-Silva 1, , Daniela Magalhães 1, , Maria Manuel Costa 1, , Ana Saavedra 1, , Joana Oliveira 1, , Filipe Cunha 1, , Eva Lau 1, , César Esteves 1, , Sandra Belo 1, , Ana Cristina Santos 4 , Paula Freitas 1, , Ana Varela 1, , Joana Queirós 1, , Flora Correia 3, , Davide Carvalho 1, & Grupo Amtco 3
1Department of Endocrinology, Diabetes and Metabolism, São João Hospital Center, Faculty of Medicine of the University of Porto, Porto, Portugal; 2Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal; 3Multidisciplinary Group for Surgical Treatment of Obesity, São João Hospital Center, Porto, Portugal; 4Clinical Epidemiology, Predictive Medicine and Public Health Department of FMUP, Porto, Portugal; 5Faculty of Nutrition and Food Sciences of University of Porto, Porto, Portugal.
Introduction: Increased blood pressure (BP) above >115/75 mmHg presents an independent association with cardiovascular events. Although there is a clear benefit of bariatric surgery on BP of hypertensive patients, the impact in non-hypertensive patients remains largely unknown. Therefore, the aim of our work was to evaluate the impact of bariatric surgery on BP of non-hypertensive obese patients.
Methods: We evaluated a cohort of 224 non-hypertensive obese patients (90.8% women) that were submitted to bariatric surgery. We analyzed systolic BP (SBP) and diastolic BP (DBP) 12 months after surgery. The impact of preoperative parameters age, sex, BMI, waist-to-hip ratio, SBP, DBP, diabetes, dyslipidemia, smoking, glomerular filtration rate, C-reactive protein; type of surgery (adjustable gastric band, Roux-en-Y gastric bypass or sleeve gastrectomy) and the weight loss after surgery was also assessed. The statistical analysis was done with Student’s t-Test, Pearson correlation and multiple regression.
Results: We observed a significant reduction of SBP (122.3±10.9 vs 116.9±14.5 mmHg, P<0.001) and PAD (77.5±8.4 vs 73.1±9.1 mmHg, P<0.001) in the 12 months after surgery. The subgroup of patients with initial-SBP 130–140 mmHg presented a greater reduction of SBP (−13.7 vs −0.2 mmHg, P<0.001) and DBP (−7.3 vs −2.5 mmHg, P<0.001). The reduction of SBP was positively associated with initial-SBP (β=0.975, P<0.001) and weight loss (β=0.202, P=0.040), and negatively with age (β=−0.249, P=0.030), BMI (β=−0.549, P=0.030) and initial-DBP (β=−0.331, P=0.015). The reduction of DBP was independently and positively associated with initial-DBP (β=0.769, P<0.001) and negatively with age (β=−0.135, P=0.044) and BMI (β=−0.335, P=0.021). The type of surgery and the other parameters analyzed did not have a significant impact on SBP or DBP variation.
Conclusion: Bariatric surgery contributes to a significant reduction of BP in non-hypertensive obese patients. The benefit appears to be more directly related to weight loss than to type of surgery. The impact of the procedure is greater in patients with higher initial-SBP, and smaller in older patients and those with higher BMI.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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