ECE2016 Eposter Presentations Obesity (69 abstracts)
Changes in SCD1 promoter DNA methylation after bariatric surgery in morbid obese patients are associated with free fatty acids levels
Sonsoles Morcillo 1, , Gracia Ma Martin-Nuñez 1 , Sara Garcia-Serrano 3, , Carolina Gutierrez-Repiso 3 , Francisca Rodriguez-Pacheco 3, , Ailec Ho-Plagaro 3 , Miguel A Alaminos-Castillo 3 , Sergio Valdes 3, , Motserrat Gonzalo 3 , Francisco J. Moreno-Ruiz 5 , Custodia Montiel-Casado 5 , Alberto Rodriguez-Cañete 5 & Eduardo Garcia-Fuentes 2,
1Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, Malaga, Spain; 2CIBER Physiopathology of Obesity and Nutrition (CIBERObn), Instituto Salud Carlos III, Malaga, Spain; 3Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Regional University Hospital, Malaga, Spain; 4CIBER of Diabetes and Associated Metabolic Disorders (CIBERDEM), Instituto de Salud Carlos III, Malaga, Spain; 5Department of Surgery, Biomedical Research Institute of Malaga (IBIMA), Regional University Hospital, Malaga, Spain.
Introduction: Epigenetic is acquiring great importance in complex diseases, providing mechanisms whereby environmental factors can influence complex diseases such as obesity and type 2 diabetes. Experimental animal and human studies have revealed the association between SCD1 and obesity and insulin resistance. The aim of this study was to evaluate whether metabolic changes after intervention are associated with DNA methylation pattern and if these changes are related to weigh loss.
Methods: The study included 65 subjects with morbid obesity underwent laparoscopic Roux-en Y gastric by-pass. These subjects were studied before and 6 months after bariatric surgery. Serum biochemical and hormone variables were measured. The methylation status of the CpG island region of the SCD1 gene promoter was determinated.
Results: DNA methylation levels of the SCD1 gene promoter increased after the intervention (1.54 vs 2.17, P<0.001). There were no significant differences in SCD1 DNA methylation levels between males and females, neither according to age (data not shown).
A negative association was observed between changes in SCD1 gene promoter methylation and changes in FFA and HOMA-IR (r=−0.442; P=0.006, and r=−0.249; P=0.035, respectively). On the opposite, a positive association was found between changes in SCD1 gene promoter methylation levels and changes in adiponectin levels (r=0.389, P=0.019).
Conclusions: The main finding of our study is the association found between changes of metabolic parameters and changes in SCD1 methylation levels after bariatric surgery.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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